PMID: 7523942Nov 1, 1994Paper

Induction of micronuclei by acute and chronic exposure in vivo to gamma rays in murine polychromatic erythrocytes

Mutation Research
P Morales-RamírezR Rodríguez-Reyes

Abstract

The effect on micronuclei (MN) frequency of in vivo exposure to different dose rates of gamma rays in murine polychromatic erythrocytes (PCE) was studied. Groups of animals were irradiated with 1.0 Gy of gamma rays administered in 10, 100, 1000 or 10,000 min; the micronucleated polychromatic-erythrocytes (MN-PCE) frequency was scored in blood samples obtained from the tail of mice at various times before, during or after irradiation. The time-response curves for the 10, 100, and 1000 min exposure were similar; however, the two first curves showed a peak at 1800 min and the last at 2400 min after exposure. The curve obtained from the 10,000 min exposure showed a plateau for a long period during and after the exposure. However, the integration of the area under the curves indicates that the damage caused by the different radiation protocols was the same, suggesting that throughout time, the lesions were not repaired but rather diluted by cell division.

References

Feb 1, 1975·Mutation Research·W Schmid
Feb 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G G Steel
Jul 1, 1990·Health Physics·J B Little
May 1, 1990·Mutation Research·N P SinghE L Schneider
Jul 1, 1990·Health Physics·M L Mendelsohn
Jul 1, 1990·Health Physics·S Abrahamson
Jul 1, 1990·Carcinogenesis·S SekiH Teraoka
Mar 1, 1989·Mutation Research·K SankaranarayananA T Natarajan
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
May 1, 1973·Mutation Research·J A Heddle
Feb 1, 1973·Journal of Theoretical Biology·A V Carrano, J A Heddle
Jul 1, 1973·Mutation Research·M von Ledebur, W Schmid

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Citations

Oct 7, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ruili HuangChristopher P Austin
Feb 6, 2014·Journal of Environmental Sciences (China)·Na ZhuNan Sang
Apr 8, 2004·Environmental Research·Guangke LiYoucai Zhao
Dec 21, 2004·Nuclear Medicine and Biology·Martha Pedraza-LópezOmar Hernández-Oviedo
Jan 1, 1997·Environmental and Molecular Mutagenesis·P Morales-RamírezR Rodríguez-Reyes

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