Induction of microsomal prostaglandin E synthase-1 in human gingival fibroblasts

Inflammation
Tülay Yucel-LindbergT Modéer

Abstract

It is well established that prostaglandin E2 (PGE2) plays an important role in inflammatory diseases including periodontitis. Previously we have reported that the inflammatory mediators interleukin-1beta, (IL-1beta) and tumor necrosis factor alpha (TNFalpha) stimulate PGE2 synthesis by inducing mRNA expression of cyclooxygenase-2 (COX-2) in human gingival fibroblasts. In present study the involvement of microsomal prostaglandin E synthase-1 (mPGES-1) in relation to PGE2 production was investigated. The results showed that IL-1beta as well as TNFalpha induced mPGES-1 mRNA and protein expression accompanied by enhanced PGE2 production in gingival fibroblasts. The anti-inflammatory steroid dexamethasone (DEX) inhibited mPGES-1 mRNA and protein expression as well as PGE2 production induced by IL-1beta or TNFalpha. The COX-2 specific inhibitor, celecoxib, in contrast to the nonspecific COX inhibitor, indomethacin, markedly reduced mPGES-1 expression induced by IL-1beta. The results demonstrate that mPGES-1 regulates PGE2 production in gingival fibroblasts stimulated by inflammatory mediators IL-1beta and TNFa. This novel pathway may be a potential target for treatment strategies of periodontal disease.

Citations

Oct 6, 2009·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hisashi ShimpoNaoki Ishiguro
Mar 1, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna KatsTülay Yucel-Lindberg
Aug 18, 2004·Current Opinion in Rheumatology·Francis Berenbaum
Jan 12, 2005·Journal of Clinical Periodontology·M MustafaT Modéer
Nov 19, 2013·Pharmaceutical Patent Analyst·Jessica K NorbergEmmanuelle J Meuillet
Oct 26, 2011·Future Medicinal Chemistry·Hui-Hua Chang, Emmanuelle J Meuillet
May 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jurairat JongthawinNisana Namwat
Jun 18, 2009·Expert Opinion on Therapeutic Targets·Jitesh P IyerAbhijit Ray
Sep 24, 2010·Journal of Periodontal Research·S KhedmatS N Ostad
Mar 19, 2016·Journal of Cellular and Molecular Medicine·Anna KatsTülay Yucel-Lindberg
Mar 26, 2011·The American Journal of Pathology·Tove BågeTülay Yucel-Lindberg
Sep 20, 2007·Pharmacological Reviews·Bengt SamuelssonPer-Johan Jakobsson
Jun 13, 2006·Cellular Signalling·Tülay Yucel-LindbergTomomi Kawakami

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