PMID: 1208882Dec 1, 1975Paper

Induction of midtrimester abortion by serial intravaginal administration of 15(S)-15-methyl-prostaglandin F2alpha (THAM) suppositories

Prostaglandins
N H Lauersen, K H Wilson

Abstract

Midtrimester abortion was successfully induced in 13 of 22 patients by serial intravaginal administration of 15(S)-15-methyl-prostaglandin F2alpha (THAM) suppositories. Nine patients, 4 nulliparas and 5 multiparas, failed to abort after 24 hours of prostaglandin administration and a concomitant infusion of oxytocin was initiated. Seven of the nine patients aborted within 7 hours of the combined therapy and one patient on methadone maintainence aborted after 17.5 hours of combined therapy, 41.5 hours after the first dose of prostaglandin. A single patient failed to abort, despite the concomitant prostaglandin-oxytocin administration and underwent surgical evacuation. The mean abortion time for the 21 successful abortions was 22.56 hours. Nulliparous patients aborted somewhat faster, mean 21.79 hours, than multiparous patients, mean 23.80 hours, but this difference was not statistically significant. In this study, one patient aborted in less than 12 hours, and 62% of the successful cases aborted within 24 hours. The plasma levels of 15-ME-PGF2alpha were analyzed by radioimmunoassay in 10 patients. Plasma prostaglandin levels rose significantly 30 minutes after the insertion of the first suppository, but there was a wide variation...Continue Reading

References

Jun 1, 1972·Prostaglandins·W E BrennerL G Staurovsky
Jan 15, 1974·American Journal of Obstetrics and Gynecology·N H Lauersen, K H Wilson
Dec 8, 2000·Steroids·M BygdemanM Swahn

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Citations

Jun 1, 1981·Journal of Pharmaceutical Sciences·T J RosemanS S Butler
Jan 1, 1983·Drug Metabolism Reviews·D P Benziger, J Edelson
Jan 1, 1977·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D VengadasalamD A Edelman

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