Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes

Toxicology Letters
J SurrallésR Marcos

Abstract

The pyrethroid insecticide fenvalerate was tested for its ability to induce mitotic micronuclei in cytokinesis-block cells of cultured human peripheral blood lymphocytes at concentrations ranging from 10 to 50 micrograms/ml. We observed that fenvalerate induces a significant increase in the frequency of micronuclei, indicating clastogenic and/or aneugenic activity. Our results complement previous data on the genotoxicity of this compound in human lymphocytes.

References

Mar 1, 1990·Mutagenesis·P Van Hummelen, M Kirsch-Volders
Jul 1, 1989·Toxicology Letters·E CarbonellR Marcos
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·Z AlmássyG J Köteles
Mar 1, 1988·Regulatory Toxicology and Pharmacology : RTP·M NehézI Dési
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
May 1, 1970·Mutation Research·M A Kastenbaum, K O Bowman
Aug 1, 1982·Mutation Research·K K ChatterjeeA Sharma

❮ Previous
Next ❯

Citations

Nov 1, 1994·Mutation Research·D K AgarwalV Sundararaman
Feb 1, 1993·Mutation Research·L VianD Gouy
Sep 2, 2003·Mutation Research·Ayla CelikUlkü Cömelekoglu
Dec 15, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Patrícia Rosa de OliveiraMaria Izabel Camargo Mathias
Aug 12, 2008·Mutation Research·Hasan Basri IlaY Kenan Daglioglu
May 4, 2011·Environmental and Molecular Mutagenesis·A GiriG D Sharma
Nov 26, 2008·Environmental and Molecular Mutagenesis·Ayşe Yavuz Kocaman, Mehmet Topaktaş
Sep 30, 2005·Cytogenetic and Genome Research·K Härkönen
Aug 20, 2016·Journal of Pesticide Science·Kaur SandeepRam S Sethi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.