PMID: 8443137Mar 1, 1993Paper

Induction of murine macrophage growth by modified LDLs

Arteriosclerosis and Thrombosis : a Journal of Vascular Biology
S YuiM Yamazaki

Abstract

We previously reported that cell membrane components and lipoproteins were able to induce the growth of murine peritoneal macrophages. The aim of the present study was to examine whether macrophage growth could also be induced by chemically modified lipoproteins, such as acetylated low density lipoprotein (acetyl-LDL) or oxidized LDL, ligands known to be endocytosed by the macrophage scavenger receptors. When murine peritoneal exudate macrophages were cultured in vitro with 25-100 micrograms/mL acetyl-LDL or oxidized LDL, significant growth was induced. On comparing the dose-response curves of these LDLs, a more potent effect was seen with oxidized LDL than acetyl-LDL, especially on resident macrophages. On the other hand, growth of these cells was not stimulated by native (unmodified) LDL or high density lipoprotein. These in vitro data revealed a new function of chemically modified LDLs as effective inducers of macrophage cell growth. This aspect may be physiologically relevant to the growth of macrophage foam cells in situ in the development of atherosclerosis.

References

Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S K BasuM S Brown
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
May 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E RosenfeldJ L Witztum
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D GordonS M Schwartz
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J FrostegårdM Gidlund
Apr 1, 1990·The Journal of Clinical Investigation·J A BerlinerA M Fogelman
Sep 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E Rosenfeld, R Ross
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W PalinskiJ L Witztum
Mar 1, 1989·Journal of Leukocyte Biology·S Yui, M Yamazaki
Jul 25, 1988·The American Journal of Cardiology·G KuR L Jackson
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M T QuinnD Steinberg
Jun 1, 1986·Journal of Leukocyte Biology·S Yui, M Yamazaki
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M T QuinnD Steinberg
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S ParthasarathyD Steinberg
Aug 1, 1985·Journal of Leukocyte Biology·M K CathcartG M Chisolm
Jan 1, 1983·Annual Review of Biochemistry·M S Brown, J L Goldstein
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·U P SteinbrecherD Steinberg

❮ Previous
Next ❯

Citations

Aug 1, 1994·Atherosclerosis·M S Penn, G M Chisolm
Jan 1, 1995·Archives of Gerontology and Geriatrics·R PaolettiS Colli
Jan 1, 1996·Free Radical Biology & Medicine·J A Berliner, J W Heinecke
Jul 28, 2013·Immunobiology·Ioana Madalina Fenyo, Anca Violeta Gafencu
Nov 26, 1998·Progress in Lipid Research·H Itabe
Aug 18, 2000·Free Radical Biology & Medicine·G M Chisolm, Y Chai
Aug 9, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Maziar RiazyUrs P Steinbrecher
Nov 14, 2013·Mediators of Inflammation·Giuseppe MaiolinoLorenzo A Calò
Nov 23, 2011·Lipids in Health and Disease·Mahaya C MatShahrul S Hamid
Jan 14, 2012·Endocrine Reviews·Jia-Ming Xu, Guo-Ping Shi
Sep 1, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A S KellyT H Inge
Feb 19, 2011·Obesity·Anne L NorrisAaron S Kelly
Jun 2, 2016·Journal of Diabetes Research·Peng ChengChi Zhang
Sep 1, 2016·Bioinformatics·Andy L OlivaresJérôme Noailly
Jul 25, 2009·Current Opinion in Lipidology·Yasushi IshigakiHideki Katagiri
Jan 28, 2010·Pediatric Diabetes·Aaron S KellyJulia Steinberger
Mar 28, 1998·The Journal of Biological Chemistry·J S MartensU P Steinbrecher
Feb 13, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S MikiY Miki
Oct 26, 2000·Current Opinion in Lipidology·M SakaiS Horiuchi
Jul 27, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ayla YalamanogluPaul W Buehler
Nov 16, 2007·Medicinal Research Reviews·R L TiwariM K Barthwal
May 30, 2003·Journal of Leukocyte Biology·John A Hamilton
Jan 15, 2000·Bioscience, Biotechnology, and Biochemistry·T SasakiS Yui
Jan 8, 2011·Biological & Pharmaceutical Bulletin·Haruyo IwasawaMasatoshi Yamazaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.