PMID: 9174252May 20, 1997Paper

Induction of myelin-associated glycoprotein expression through neuron-oligodendrocyte contact

Brain Research. Developmental Brain Research
Y MatsudaH Yamamoto

Abstract

The role of neurons on expression of myelin-associated glycoprotein (MAG) in oligodendrocytes and oligodendroglial differentiation was examined. Primary cultures of oligodendrocytes prepared from neonatal mouse brains were co-cultured with neuronal cells derived from embryonal carcinoma P19 cells. The levels of MAG mRNAs following this co-culture were determined by reverse transcription (RT)-PCR. In oligodendrocytes co-cultured in direct contact with P19-derived neurons, the levels of MAG mRNAs, particularly that of the L-type isoform, were markedly higher than those in cultures without any neuronal cells. On the other hand, when the P19-derived neurons were present, but not in direct contact, no significant induction of MAG expression was found, though oligodendrocytes appeared to mature morphologically. The L-MAG expression was also stimulated when just the neuronal cell membrane fraction was added, which implies that there might be some effecter(s) in the cell membrane which are possibly exerting a signal transduction for myelin formation. These results suggest that morphological differentiation and functional maturation of oligodendrocytes are due to independent factors. The former is caused by some humoral factor(s) libera...Continue Reading

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Citations

Jan 13, 2001·Brain Research. Developmental Brain Research·P E KnappM Mata
Jan 15, 2003·Journal of Neuroscience Research·M ErbN Schaeren-Wiemers
Feb 6, 2003·The Journal of Clinical Investigation·Tomonori KaifuToshiyuki Takai
Jul 22, 1998·Microscopy Research and Technique·I GriffithsK A Nave
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh

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