PMID: 9191098Jun 1, 1997Paper

Induction of Na+/myo-inositol co-transporter mRNA after rat cryogenic injury

Brain Research. Molecular Brain Research
T YamashitaM Tohyama

Abstract

Myo-inositol is one of the major organic osmolytes in the brain. It is stored in the cells by the Na+/myo-inositol co-transporter (SMIT) which is regulated by extracellular osmolality. First, in order to confirm that local change of the osmolality induces alteration of the SMIT mRNA in brain, we examined change of SMIT mRNA of the animals with hypertonic NaCl application to the cortex. Application of hypertonic NaCl up-regulated the SMIT mRNA expression widely surrounding the application site. We next investigated the role of SMIT in brain during vasogenic edema, we examined expression of SMIT mRNA in the rat brain after cryogenic injury. The expression of SMIT mRNA was markedly increased 12 h after surgery and the induction of the mRNA extended to the entire cortex of the affected side. Up-regulated expression was found predominantly in the neurons in remote areas. The induction of SMIT mRNA was found until the 3rd day after surgery. These findings suggest that osmotic stress may spread over a wide area in the cortex in case of vasogenic edema produced by cryogenic injury and that the cells respond to this stress by increasing SMIT expression.

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Citations

Jun 19, 2007·Neurosurgical Review·R TyagiJ Jallo
Feb 13, 2001·Brain Research. Molecular Brain Research·T UedaS Shimada
Jul 17, 1999·Brain Research. Molecular Brain Research·M NonakaT Hayakawa
Jul 6, 2002·Neuroscience Letters·Noritaka AiharaShoichi Shimada
Oct 3, 2002·Journal of Neurochemistry·Stephen K FisherBernard W Agranoff
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yusuke WatanabeTadashi Yamamoto
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N J RobertsonA D Edwards
Feb 15, 2005·Legal Medicine·Akiko KiyoshimaNoriaki Ikeda
May 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nathan A DaviesRajiv Jalan
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Mar 10, 2001·The Journal of Trauma·J A DoyleD B Hoyt
Oct 13, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rym AouameurJean-Yves Lapointe
Apr 27, 1999·Journal of Neurochemistry·T YamashitaM Tohyama

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