PMID: 6980965Sep 1, 1982Paper

Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus

The Journal of Experimental Medicine
D H Schwartz, P C Doherty

Abstract

Thymocytes and spleen cells from C57BL/6 mice (H-2b) neonatally tolerized to H-2k alloantigens do not generate an anti-vaccinia response restricted to H-2Kk when adoptively transferred to appropriate irradiated hosts. This is in sharp contrast to the case for negatively selected C57BL/6 spleen cells acutely depleted of alloreactivity. No evidence for suppression was found in cell mixture experiments. We have shown elsewhere that our neonatally tolerized animals have a centrally induced delection-type tolerance in the absence of obvious suppression.2 We now suggest that in the neonatally tolerized mouse, chronic, central delection of anti-H-2k clones during early T cell ontogeny eliminates the major source of cells able to give rise, via somatic mutation and expansion, to anti-H-2Kk + vaccinia specific cytotoxic T lymphocyte precursors (CTL-P) in the adult. A similar mechanism may operate in the (k + b) leads to b chimera; however, the presence of H-2kxb accessory and presenting cells may permit the eventual generation (via cross-stimulation) of an H-2k-restricted vaccinia-specific repertoire. This would account for our observation of such "aberrant recognition" CTL-P emerging in the spleens of older (k x b) leads to b chimeras.

References

Jan 1, 1978·Immunological Reviews·O Stutman
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D W Thomas, E M Shevach
Jan 1, 1978·Scandinavian Journal of Immunology·R M GroczynskiJ E Till
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J R Bennink, P C Doherty
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R FinbergB Benacerraf
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Oct 1, 1979·The Journal of Experimental Medicine·J Forman, J W Streilein
Mar 1, 1974·Journal of Immunological Methods·K LaffertyI Misko
Jan 1, 1980·Scandinavian Journal of Immunology·P C Doherty, J R Bennink
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G J Nossal, B L Pike
Jan 1, 1981·Journal of Immunological Methods·J R Bennink, P C Doherty
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A Müllbacher

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