Induction of nestin synthesis in rat brain cells by ischemic damage

Neuroscience and Behavioral Physiology
D E KorzhevskiĭT D Vlasov

Abstract

Nestin, an intermediate filament protein, is known to be expressed in proliferating and provisional cells in the forming mammalian brain, disappearing on differentiation. The aim of the present work was to identify the morphological types and locations of cells regaining the ability to synthesize nestin after transient total brain ischemia in rats. Transient ischemia was found to be followed by the induction of nestin synthesis in astrocytes in the damaged area; these cells acquired structural features not characteristic of the adult brain, and these persisted in the long term. Nestin synthesis was also induced in proliferation-capable undifferentiated cells in the subventricular zone. The acquisition by astrocytes of some of the phenotypic features of immature glial cells, however, does not provide grounds for the notion that they were transformed into neural stem cells.

References

Apr 29, 1998·Microscopy Research and Technique·W Wittkowski
Dec 12, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K JinD A Greenberg
Jul 30, 2003·Brain Research·Takehiro NakamuraRichard F Keep
Dec 14, 2005·International Review of Cytology·Esteban M RodríguezPedro Amat
Dec 22, 2005·The European Journal of Neuroscience·Carl Ernst, Brian R Christie
Mar 28, 2006·Neurologia Medico-chirurgica·Tatsuya ShimizuNobuhito Saito

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Citations

Jan 12, 2010·Journal of Internal Medicine·G Oberdörster
Aug 5, 2014·BMC Veterinary Research·Alice WongClare E Yellowley
Jun 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Joanna M GouldSandrine Willaime-Morawek

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