PMID: 7087896Jan 1, 1982Paper

Induction of neuroblastoma maturation by a new chemotherapy protocol

Medical and Pediatric Oncology
J H RaafM Luna

Abstract

Five patients, 1.5 to 9 years old, were treated at M.D. Anderson Hospital for Stage III of IV neuroblastoma. Each was entered into a chemotherapy protocol which included cyclophosphamide, vincristine, 5-trifluoromethyl-2'-deoxyuridine (F3TdR), and papaverine, and each responded with marked reduction in size of the abdominal tumor mass. All patients then underwent exploratory laparotomy and resection or biopsy of residual tumor. In three cases, histological examination of the treated tumor showed ganglioneuroblastoma with predominance of mature cells; one patient had a mature ganglioneuroma, whereas only necrotic tissue was obtained from the fifth patient. These findings support the hypothesis that this chemotherapy protocol can induce neuroblastoma maturation.

References

Sep 1, 1976·Journal of the National Cancer Institute·L HelsonS K Das
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·I E HellströmA H Bill
Jan 1, 1968·Annals of Surgery·J FortnerM L Murphy

Citations

Jan 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D MecoR Riccardi
Sep 17, 2013·Clinical Endocrinology·Hassan ShawaMouhammed Amir Habra
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N L Carlsen
May 22, 2016·Japanese Journal of Clinical Oncology·Tomoko IeharaHajime Hosoi
Apr 1, 2014·Journal of Computer Assisted Tomography·Na Yeon HanJae Yun Song
Nov 21, 2013·Korean Journal of Pathology·Go Eun BaeJung-Sun Kim

Related Concepts

Adrenal Cancer
Antineoplastic Agents
Biopsy
Drug Evaluation
Polychemotherapy
Ganglioneuroma
Neuroblastoma
Relapse

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