Induction of Neurorestoration From Endogenous Stem Cells

Cell Transplantation
Ji Hea YuSung-Rae Cho

Abstract

Neural stem cells (NSCs) persist in the subventricular zone lining the ventricles of the adult brain. The resident stem/progenitor cells can be stimulated in vivo by neurotrophic factors, hematopoietic growth factors, magnetic stimulation, and/or physical exercise. In both animals and humans, the differentiation and survival of neurons arising from the subventricular zone may also be regulated by the trophic factors. Since stem/progenitor cells present in the adult brain and the production of new neurons occurs at specific sites, there is a possibility for the treatment of incurable neurological diseases. It might be feasible to induce neurogenesis, which would be particularly efficacious in the treatment of striatal neurodegenerative conditions such as Huntington's disease, as well as cerebrovascular diseases such as ischemic stroke and cerebral palsy, conditions that are widely seen in the clinics. Understanding of the molecular control of endogenous NSC activation and progenitor cell mobilization will likely provide many new opportunities as therapeutic strategies. In this review, we focus on endogenous stem/progenitor cell activation that occurs in response to exogenous factors including neurotrophic factors, hematopoietic ...Continue Reading

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Citations

Aug 16, 2016·Molecular Neurobiology·Anahita KiasatdolatabadiJafar Ai
Dec 5, 2017·Stem Cells International·Cesar ReisJohn H Zhang
Jan 31, 2020·Neural Regeneration Research·Ya ZhengLi-Ming Cheng
Oct 13, 2020·Curēus·Varun VankeshwaramSafeera Khan

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Methods Mentioned

BETA
transgenic

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