PMID: 9444999Jan 28, 1998Paper

Induction of neutralizing antibodies to T-cell line-adapted and primary human immunodeficiency virus type 1 isolates with a prime-boost vaccine regimen in chimpanzees

Journal of Virology
S Zolla-PaznerM Robert-Guroff

Abstract

Five chimpanzees were immunized by administration of one or more intranasal priming doses of one to three recombinant adenoviruses containing a gp160 insert from human immunodeficiency virus type 1 (HIV-1) MN (HIV-1MN) followed by one or more boosts of recombinant HIV-1SF2 gp120 delivered intramuscularly with MF59 adjuvant. This regimen resulted in humoral immune responses in three of five animals. Humoral responses included immunochemically active anti-H1V-1 antibodies (Abs) directed to recombinant gp120 and neutralizing Abs reactive with T-cell-line-adapted HIV-1MN and HIV-1SF2. In addition, neutralizing activity was detected to the two homologous primary isolates and to two of three heterologous primary isolates which, like the immunizing strains, can use CXCR4 as a coreceptor for infection. The three animals with detectable neutralizing Abs and a fourth exhibiting the best cytotoxic T-lymphocyte response were protected from a low-dose intravenous challenge with a cell-free HIV-1SF2 primary isolate administered 4 weeks after the last boost. Animals were rested for 46 weeks and then rechallenged, without a boost, with an eightfold-higher challenge dose of HIV-1SF2. The three animals with persistent neutralizing Abs were again...Continue Reading

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Citations

Dec 5, 1998·AIDS Research and Human Retroviruses·J S Cairns, N Sarver
Jan 10, 2003·Journal of Medical Primatology·Yvette Y Edghill-SmithMarjorie Robert-Guroff
Jul 23, 2005·Viral Immunology·Michael SantosuossoZhou Xing
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon J DraperAdrian V S Hill
Aug 6, 2003·Expert Review of Vaccines·Audino Podda, Giuseppe Del Giudice
Jun 27, 2001·FEMS Microbiology Letters·M J Schnell
Feb 13, 2013·The Journal of Experimental Medicine·Laura E McCoy, Robin A Weiss
Mar 17, 2004·AIDS Research and Human Retroviruses·Nina MalkevitchMarjorie Robert-Guroff
Aug 13, 2008·Expert Opinion on Biological Therapy·L Jean Patterson, Marjorie Robert-Guroff
Oct 9, 2009·International Reviews of Immunology·Antonella CaputoBarbara Ensoli
Oct 2, 2008·Alternatives to Laboratory Animals : ATLA·Jarrod Bailey

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