Induction of nitric oxide production by polyosides from the cell walls of Streptococcus mutans OMZ 175, a gram-positive bacterium, in the rat aorta.

Infection and Immunity
V MartinA Beretz

Abstract

The cardiovascular dysfunctions associated with septic shock induced by gram-negative or gram-positive bacteria (gram-positive or gram-negative septic shock) are comparable. In gram-negative septic shock, lipopolysaccharide (LPS) induces nitric oxide (NO) synthase, which contributes to the vascular hypotension and hyporeactivity to vasoconstrictors. The role of NO in gram-positive septic shock and the nature of the bacterial wall components responsible for the vascular effects of gram-positive bacteria are not well known. This study investigated the vascular effects of cell wall serotype polyosides, rhamnose glucose polymers (RGPs), from Streptococcus mutans, in comparison with lipoteichoic acid (LTA) from Staphylococcus aureus, on the induction of NO synthase activity in the rat aorta. We show that 10 microg of both RGPs and LTA per ml induced hyporeactivity to noradrenaline, L-arginine-induced relaxation, increases of 2.2- and 7.8-fold, respectively, of cyclic GMP production, and increases of 7- and 12-fold in nitrite release. All of these effects appeared after several hours of incubation and were inhibited by N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase. Electron paramagnetic resonance spin t...Continue Reading

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Citations

Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A L KleschyovJ C Stoclet
Jul 15, 1999·Biochemical and Biophysical Research Communications·T MatsunagaT Komoda
Apr 26, 2002·Vaccine·Toshihiko KogaYoshio Nakano
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Aug 12, 1999·European Journal of Pharmacology·J C StocletA L Kleschyov
Aug 16, 2001·Journal of Cardiothoracic and Vascular Anesthesia·A KumarJ E Parrillo

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