Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists

Circulation Research
D Ungureanu-LongroisT W Smith

Abstract

Recent evidence has documented that increased activity of an inducible nitric oxide synthase (iNOS; type 2 NO synthase) in primary isolates of adult rat ventricular myocytes after exposure to soluble mediators in medium conditioned by lipopolysaccharide-activated macrophages is associated with a decrease in their contractile responsiveness to beta-adrenergic agonists. It remained unclear which specific inflammatory cytokines in this medium contribute to the induction of iNOS activity in myocytes and whether induction of iNOS would result in an obligatory decline in contractile function. Interleukin (IL)-1 beta and tumor necrosis factor-alpha (TNF-alpha) were both present in the lipopolysaccharide-activated macrophage-conditioned medium. However, only IL-1 receptor antagonist and not an anti-rat TNF-alpha antiserum diminished the extent of iNOS induction in myocytes exposed to this medium and prevented a decline in contractile responsiveness to isoproterenol. When recombinant cytokines were used, IL-1 beta, TNF-alpha, and IFN-gamma each induced iNOS activity in cardiac myocytes at 24 hours. However, only the combination of IL-1 beta and IFN-gamma reproducibly caused contractile dysfunction in cardiac myocytes. Among the constitu...Continue Reading

References

Jul 15, 1992·Biochemical and Biophysical Research Communications·P López-AparicioE Degerman
Sep 4, 1992·Cell·C J Lowenstein, S H Snyder
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Feb 1, 1991·Journal of Molecular and Cellular Cardiology·A VolzP Schwartz
Jan 15, 1988·Biochemical and Biophysical Research Communications·T GulickL G Lange
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·A M Lefer, M J Rovetto
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L BalligandT Michel
Jun 30, 1993·Biochemical and Biophysical Research Communications·P López-AparicioE Degerman
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C J LowensteinW J Murphy
Jul 15, 1993·Biochemical and Biophysical Research Communications·T InoueT Ogihara
Jul 1, 1992·Trends in Cardiovascular Medicine·L G Lange, G F Schreiner

❮ Previous
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Citations

Oct 23, 1997·Clinical Cardiology·U Ikeda, K Shimada
Dec 19, 2001·Microscopy Research and Technique·W BlochB K Fleischmann
Jul 3, 2010·Cardiovascular Drugs and Therapy·Willem J Remme
Jan 17, 2007·Molecular and Cellular Biochemistry·Jacquelyn M SmithGordon M Wahler
Sep 28, 2012·Journal of Cardiovascular Translational Research·Melissa L Martin, Burns C Blaxall
Jun 14, 2005·Pharmacology & Therapeutics·R SchulzJ-L Balligand
May 30, 1996·The American Journal of Cardiology·R A Kelly, T W Smith
Aug 9, 2002·European Journal of Pharmacology·Susanna PriceJane A Mitchell
Sep 1, 1995·Progress in Cardiovascular Diseases·J M Hare, W S Colucci
Apr 13, 2000·Pharmacology & Therapeutics·A M Shah, P A MacCarthy
Mar 6, 1998·International Journal of Cardiology·A Matsumori
May 1, 1997·Journal of the American College of Cardiology·W J PaulusH Drexler
Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·R H RitchieG J Dusting
Jul 7, 2001·Human Gene Therapy·A NakanoJ I Miyazaki
Jan 24, 2002·Current Opinion in Critical Care·P B MassionJ L Balligand
Jan 22, 2005·Echocardiography·Holger P Salazar, James V Talano
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·Z M QuezadoC Natanson
Apr 15, 1996·The Journal of Clinical Investigation·C J LowensteinA Herskowitz
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·W L GrossR A Kelly
Apr 21, 2010·Heart Failure Reviews·Mona HedayatNima Rezaei
Oct 24, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·E M SiaghyP M Mertes
Jun 2, 2005·Expert Opinion on Investigational Drugs·Lars GullestadPål Aukrust
May 1, 1997·Kidney International·P Pintavorn, B J Ballermann
Mar 28, 2007·Heart Failure Clinics·Giuseppe Barbaro
Jun 30, 2004·Pharmacotherapy·Brian F McBride, C Michael White
Nov 15, 2007·European Journal of Heart Failure·S MoniotteJ-L Balligand
Jun 1, 2005·The American Journal of Cardiology·Lars Gullestad, Pål Aukrust
Aug 18, 2005·Cytokine·Hongkui JinNicholas F Paoni
Oct 1, 1998·Journal of Cardiac Failure·M A Arstall, R A Kelly
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Natalia N PetrashevskayaArnold Schwartz
Sep 28, 2000·Cell Calcium·N Kraus-Friedmann
Jan 20, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kelly M McLeanJeffrey M Pearl

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