PMID: 8584246Oct 20, 1995Paper

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

Neuroscience Letters
K AbeY Itoyama

Abstract

Spinal cords of sporadic cases with amyotrophic lateral sclerosis (ALS) and normal controls were immunohistochemically examined using antibodies for Cu/Zn superoxide dismutase (SOD) and nitrotyrosine (NT). Immunoreactivity for Cu/Zn SOD of the motor neurons was not different between the ALS and controls. In contrast, immunoreactivity for NT was densely detected in motor neurons of ALS but was not or was only minimally detected in those of controls. The staining was also found in the axons of motor neurons of ALS, but was not found in the controls. These results suggest that nitration of protein-tyrosine residue is upregulated in motor neurons of the spinal cord of ALS.

References

Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·S L Marklund
Jun 1, 1995·Human Molecular Genetics·H X DengT Siddique
Dec 1, 1993·Nature Genetics·M AokiK Abe
Feb 1, 1994·Neurology·I RaineroD R McLachlan
Aug 12, 1993·Nature·J S BeckmanW H Koppenol
Nov 1, 1976·Plant Physiology·J E Baker

❮ Previous
Next ❯

Citations

Aug 25, 2001·Biochemical and Biophysical Research Communications·L T KnappE Klann
Nov 16, 2011·Journal of Bioenergetics and Biomembranes·Lee J Martin
Aug 21, 2008·Journal of Molecular Neuroscience : MN·Nirit LevDaniel Offen
Dec 31, 2003·Trends in Neurosciences·Shyam D Rao, John H Weiss
Aug 21, 2001·Brain Research·P ManningP J Shaw
Dec 14, 1999·Journal of the Neurological Sciences·M J Strong
Feb 12, 1999·Brain Research. Brain Research Reviews·B M Morrison, J H Morrison
Oct 19, 1999·Brain Research. Brain Research Reviews·F TorreillesJ Torreilles
Jan 5, 2000·Neuroscience Research·F Irie, Y Hirabayashi
Apr 20, 2001·Brain Research. Molecular Brain Research·H WaritaK Abe
Oct 2, 2001·Archives of Medical Research·R B MaccioniL Barbeito
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Koichi KashiwadoTakamichi Hattori
Aug 30, 2000·Neuroscience Letters·S SasakiM Iwata
Jun 13, 1997·Neuroscience Letters·H SuzukiY Itoyama
Oct 18, 2000·Free Radical Biology & Medicine·M BogdanovM Cudkowicz
Apr 30, 2002·Free Radical Biology & Medicine·M Flint Beal
Sep 19, 1998·Free Radical Biology & Medicine·W H Koppenol
Apr 27, 2001·Journal of the American Society for Mass Spectrometry·A SarverB W Gibson
Mar 27, 2004·Neuropathology and Applied Neurobiology·G J Clowry, S McHanwell
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiT P Misko
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P LeeR P Roos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.