PMID: 8960134Dec 2, 1996Paper

Induction of oh8Gua glycosylase in rat kidneys by potassium bromate (KBrO3), a renal oxidative carcinogen

Mutation Research
Y S LeeM H Chung

Abstract

It has been suggested that 8-hydroxyguanine (oh8Gua), a DNA adduct formed by active oxygens, impairs the maintenance of genetic integrity, oh8Gua glycosylase removes oh8Gua residues as a free base from DNA strands. In E. coli, it has been demonstrated that oh8Gua glycosylase is induced in response to oxidative stress, but the oxidative inducibility in mammalian tissues has not yet been studied. In the present study, the inducibility of oh8Gua glycosylase was tested by comparing activity changes of this enzyme in the kidney and the liver of rats treated with potassium bromate (KBrO3). KBrO3 is known to cause oxidative damage to the kidney but not to other organs. With a single dose of KBrO3 (80 mg/kg, i.p.), activity in the kidney was found to increase significantly at 3 h compared to that at zero time. At 6 h, activity peaked, showing a 6-fold increase over that at zero time. Thereafter, it decreased and returned to its zero time level at 12 h. With increasing doses of KBrO3 (up to 160 mg/kg, i.p.), activity increased linearly with increased dosage, and over 40 mg/kg, i.p., activity increased to a level significantly higher than that in the control. In contrast to the time- and dose-dependent changes in activity in the kidney, ...Continue Reading

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Citations

Oct 3, 2002·Cancer Letters·Yih-Horng ShiaoDouglas C Wolf
Feb 6, 2002·Free Radical Biology & Medicine·Jin-Won HyunMyung-Hee Chung
Jun 28, 2002·Free Radical Biology & Medicine·Susan S Wallace
Aug 6, 2003·Free Radical Biology & Medicine·Pratibha Mistry, Karl E Herbert
Oct 9, 1999·Free Radical Biology & Medicine·R PamplonaG Barja
Mar 10, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y J ParkM H Chung
Feb 8, 2006·Toxicology·Martha M Moore, Tao Chen
Mar 5, 2013·Experimental Gerontology·Ines Sanchez-Roman, Gustavo Barja
Mar 23, 2011·Journal of Aging Research·Reinald Pamplona
Nov 30, 2011·International Journal of Toxicology·F Alan Andersen
Apr 3, 2003·Nature Reviews. Cancer·S Perwez HussainCurtis C Harris
Aug 8, 1997·The Journal of Biological Chemistry·K B Beckman, B N Ames
Aug 2, 2020·Environmental Science and Pollution Research International·Gökçe ÖztürkEmine Yalçın
Jan 6, 2021·Ecotoxicology and Environmental Safety·Xiao-Ping XuXing-Ming Wang

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