PMID: 9533293Apr 9, 1998Paper

Induction of onion-induced haemolytic anaemia in dogs with sodium n-propylthiosulphate

The Veterinary Record
O YamatoY Maede

Abstract

The haemolytic effect of sodium n-propylthiosulphate, which had been isolated from boiled onions, was studied to determine whether it could be one of the agents responsible for induced haemolytic anaemia in dogs. The oral administration of 500 mumol/kg bodyweight of the compound to dogs resulted in a haemolytic anaemia associated with an increase of Heinz body formation in erythrocytes, which was more severe in dogs with the hereditary condition which results in erythrocytes with high concentrations of reduced glutathione and potassium than in normal dogs. In the affected dogs there was a 10-fold increase in the concentration of oxidised glutathione in their erythrocytes 12 hours after the administration of the compound, whereas in normal dogs there was almost no change.

References

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Jan 1, 1994·Bioscience, Biotechnology, and Biochemistry·O YamatoY Maede

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Citations

Aug 13, 2003·Bioscience, Biotechnology, and Biochemistry·Osamu YamatoTeruhiko Yoshihara
Sep 1, 2009·Interdisciplinary Toxicology·Natália KovalkovičováVáclav Sutiak
Jan 7, 2005·Journal of the American Animal Hospital Association·Osamu YamatoYoshimitsu Maede
May 26, 1999·The Journal of Veterinary Medical Science·H M SelimY Maede
Mar 2, 2006·Experimental Animals·Hideharu OchiaiHiroshi Fujise
Oct 6, 2006·Acta Veterinaria Hungarica·A MáthéJ Reiczigel
Feb 21, 2002·Journal of Agricultural and Food Chemistry·Qiuhui HuTeruhiko Yoshihara

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