PMID: 2511733Oct 1, 1989Paper

Induction of oral cancer by 7,12-dimethylbenz[a]anthracene in rats with liver cirrhosis

Acta Odontologica Scandinavica
U Lekholm, G Stenman

Abstract

The effects of carbon tetrachloride-induced liver cirrhosis and xerostomia on oral carcinogenesis were studied in rats given the lipid-soluble carcinogen 7,12-dimethylbenz-[a]anthracene (DMBA). The first carcinoma was detected after only 1 month of DMBA applications. After a further 8 months 85% of the animals had developed one or more squamous cell carcinomas. The latency period for DMBA-induced oral cancer in cirrhotic rats with xerostomia was markedly reduced in comparison with previous findings from xerostomic rats without liver cirrhosis. The results support earlier epidemiologic studies indicating a relationship between liver cirrhosis and oral cancer.

Citations

May 11, 2016·The Journal of Laryngology and Otology·K-P ChangH-J Chang

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