PMID: 9545109Apr 17, 1998Paper

Induction of oral tolerance in human autoimmune thyroid disease

Thyroid : Official Journal of the American Thyroid Association
S LeeL J DeGroot

Abstract

Our laboratory has reported suppression of experimental autoimmune thyroiditis in mice by oral feeding with antigen. Based on these data, we considered it possible that oral feeding of animal thyroglobulin (TG) might induce tolerance to antigen in human autoimmune thyroid disease (AITD). Thirteen patients receiving thyroid hormone replacement with synthetic thyroxine (T4) (five patients with Graves' disease, treated with radioiodine 4 to 11 years ago and eight patients with Hashimoto's thyroiditis) were randomly assigned to a test group (switched to replacement with desiccated thyroid from porcine thyroids) and a control group (maintained on synthetic T4). Humoral and cellular immunologic parameters were evaluated in addition to clinical parameters before and every 3 months after the onset of study for a year. At the onset of study, there was no difference in clinical parameters, or humoral and cellular immunity to thyroid autoantigens, except a finding that one thyroid peroxidase (TPO) peptide (100 approximately 119) appeared to stimulate peripheral blood mononuclear cells (PBMC) during in vitro microproliferation assay more in the test group than control group (p = 0.051 by t test). Additionally, almost all of TPO and thyrotr...Continue Reading

References

Oct 1, 1991·The Journal of Experimental Medicine·A MillerH L Weiner
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z J ZhangH L Weiner
Nov 1, 1989·Endocrine Reviews·L J DeGroot, J Quintans
Apr 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M E FisfalenK Soltani
Jun 1, 1988·Scandinavian Journal of Immunology·Y Eishi, P McCullagh
Feb 1, 1981·European Journal of Immunology·M ElRehewyN R Rose
Jun 1, 1996·Endocrinology·V C GuimaraesL J DeGroot
Jan 1, 1960·The Journal of Clinical Endocrinology and Metabolism·L J DEGROOT, E CARVALHO

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Citations

Dec 13, 2006·Clinical & Developmental Immunology·Ana M C Faria, Howard L Weiner
Jan 1, 2005·Indian Journal of Clinical Biochemistry : IJCB·Manorama SwainBinoy Kumar Mohanty
Sep 11, 1999·Thyroid : Official Journal of the American Thyroid Association·R M ColzaniL E Braverman
Apr 12, 2001·Allergy·L MayerL Toy
Jan 16, 2008·Expert Opinion on Biological Therapy·Thomas E IchimWei-Ping Min
Oct 11, 2012·Experimental and Molecular Pathology·Tim MeyerMartin Zeitz
Jul 10, 2007·The Veterinary Clinics of North America. Small Animal Practice·Peter A GrahamRaymond F Nachreiner
Apr 10, 2007·Journal of Reproductive Immunology·Li FuBing-Yu Huang
Feb 1, 2005·Annals of the New York Academy of Sciences·Howard L Weiner
Jun 30, 2009·Human Immunology·Yaron Ilan
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L Mayer
Sep 26, 2001·The Veterinary Clinics of North America. Small Animal Practice·P A GrahamA L Provencher-Bolliger
Mar 27, 2012·The Medical Clinics of North America·Marius N StanRebecca S Bahn
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Eran Israeli, Yaron Ilan
Mar 27, 2003·Nature Reviews. Immunology·Matthias G von Herrath, Leonard C Harrison
Dec 2, 2005·International Reviews of Immunology·Mauro RossiDiomira Luongo
Oct 5, 2013·Endocrine Reviews·Sandra M McLachlan, Basil Rapoport
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Beate KargesWolfram Karges
Jul 29, 2005·Immunological Reviews·Ana M C Faria, Howard L Weiner
May 20, 2015·World Journal of Gastroenterology : WJG·Eran IsraeliYaron Ilan

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