Induction of Osteogenic Differentiation of Human Adipose-Derived Stem Cells by a Novel Self-Supporting Graphene Hydrogel Film and the Possible Underlying Mechanism

ACS Applied Materials & Interfaces
Cheng-Qi LyuDe-Rong Zou

Abstract

Graphene and its derivatives have received increasing attention from scientists in the field of biomedical sciences because of their unique physical properties, which are responsible for their interesting biological functions. With a range of extraordinary properties such as high surface area, high mechanical strength, and ease of functionalization, graphene is considered highly promising for application in bone tissue engineering. Here, we examined the effect of using a self-supporting graphene hydrogel (SGH) film to induce the osteogenic differentiation of human adipose-derived stem cells (hADSCs). In comparison to conventional graphene and carbon fiber films, the SGH film had higher mechanical strength and flexibility. Moreover, we found that the SGH film was nontoxic and biocompatible. Of particular interest is the fact that the film alone could stimulate the osteogenic differentiation of hADSCs, independent of additional chemical inducers. Such effects are stronger for the SGH film than for graphene or carbon fiber films, although the induction capacity of the SGH film is not as high as that of the osteogenic-induced medium. The excellent osteoinductivity of the SGH film is closely related to its remarkable physical proper...Continue Reading

References

Jul 9, 1999·Journal of Biomedical Materials Research·A P Valagão Amadeu do SerroW Norde
Apr 8, 2004·Developmental Cell·Rowena McBeathChristopher S Chen
Nov 10, 2005·Journal of Biomedical Materials Research. Part a·Yingjun WangXiaofeng Chen
Oct 1, 1995·Applied and Environmental Microbiology·D DaffonchioW Verstraete
Feb 10, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hue H LuuTong-Chuan He
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Catherine M CowanKang Ting
Apr 22, 2008·Journal of Anatomy·Daniel HowardScott J Roberts
Sep 17, 2009·The International Journal of Developmental Biology·Hiromitsu KajiyamaMakoto Asashima
Sep 28, 2010·Regenerative Medicine·Gregory YourekGwendolen C Reilly
Nov 18, 2010·Methods in Molecular Biology·Kellie J WilliamsKenneth R Bondioli
Nov 3, 2012·Expert Review of Medical Devices·Aldo R BoccacciniAndreas Arkudas
Nov 21, 2012·Accounts of Chemical Research·Cyrill BussyKostas Kostarelos
Jan 19, 2013·Chemical Reviews·Xiangang Hu, Qixing Zhou
Feb 5, 2013·Journal of Biomedical Materials Research. Part a·Xiaoming LiFumio Watari
Mar 16, 2013·Advanced Materials·Dimitrios BitounisKostas Kostarelos
Jun 29, 2013·Methods in Molecular Biology·Miriam ArañaFelipe Prosper
Oct 24, 2013·Biochemical and Biophysical Research Communications·Ji Sun NamKyung Rae Kim
Jan 21, 2014·Cytotherapy·Miguel Angel Martin-PiedraMiguel Alaminos
Jan 24, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mehdi MogharabiMohammad Ali Faramarzi
Aug 26, 2014·Biochemical and Biophysical Research Communications·Tae-Jin LeeByung-Soo Kim
Sep 23, 2014·Biomaterials·Hyun-Ji ParkSeung-Woo Cho
Apr 2, 2015·Clinics in Plastic Surgery·Sahil K KapurAdam J Katz
May 7, 2015·Advanced Healthcare Materials·Cassandra L Weaver, Xinyan Tracy Cui
May 21, 2015·Journal of Biomedical Nanotechnology·Haiqing DongDonglu Shi

❮ Previous
Next ❯

Citations

Aug 18, 2017·Chemical Society Reviews·Qiutong HuangJianzhong Du
Apr 4, 2018·Journal of Biomedical Materials Research. Part a·Dorsa MohammadrezaeiLobat Tayebi
Oct 17, 2019·Journal of Biomedical Materials Research. Part a·Muhammad QasimNae Yoon Lee
Apr 2, 2016·Materials·Gianluca TozziMarta Roldo
Oct 17, 2019·International Journal of Molecular Sciences·Sorina DinescuAnca Hermenean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Min WangXue-tao Pei
Journal of Translational Medicine
Eriberto BressanBarbara Zavan
© 2021 Meta ULC. All rights reserved