Induction of OX40, a receptor of gp34, on T cells by trans-acting transcriptional activator, Tax, of human T-cell leukemia virus type I

Japanese Journal of Cancer Research : Gann
N HigashimuraKazuo Sugamura

Abstract

gp34, which we had identified as a target molecule of the trans-activation by Tax of human T-cell leukemia virus type I (HTLV-I), has been found to bind OX40, a member of the tumor necrosis factor receptor family, resulting in growth stimulation of activated T cells. We here demonstrate that not only gp34 (OX40L), but also OX40 can be transcriptionally activated by Tax. Three Tax-producing human T-cell lines carrying the HTLV-I genome expressed OX40 on their surfaces. Furthermore, Tax-induced transcriptional activation of OX40 was shown in Tax-inducible JPX-9 cells. These results demonstrate that both OX40 and its ligand (gp34) are constitutively expressed on the surfaces of Tax-expressing T lymphocytes, suggesting that the OX40L/OX40 system contributes to growth stimulation of the virus-infected T cells.

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Citations

Nov 1, 1996·Journal of Clinical Immunology·T Uchiyama
Nov 6, 2002·International Journal of Hematology·Akane KunitomiTakashi Uchiyama
Sep 11, 2002·Cytokine & Growth Factor Reviews·Yoichiro Iwakura
Jan 19, 2000·The Journal of Experimental Medicine·K MurataK Sugamura
Jul 2, 2015·Retrovirology·Yuetsu TanakaMasataka Nakamura
May 11, 2001·Japanese Journal of Cancer Research : Gann·N TakasawaK Sugamura
Jan 1, 1997·Annual Review of Immunology·T Uchiyama
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Kiyoshi KuriharaMari Kannagi
Sep 13, 2005·Oncogene·Shao-Cong Sun, Shoji Yamaoka
Dec 20, 2005·International Immunology·Shuming ChenKazuo Sugamura
Jul 26, 2011·International Journal of Dermatology·Masahiro AmanoFrancisco A Kerdel
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R PankowS Bulfone-Paus
Jan 10, 2018·Frontiers in Microbiology·Yoshimi Enose-AkahataSteven Jacobson
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L C NdhlovuK Sugamura
Apr 25, 2000·Biochemical and Biophysical Research Communications·Y SatakeK Okumura

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