PMID: 9434882Jan 22, 1998Paper

Induction of p53 protein expression by sodium arsenite

Mutation Research
A M SalazarE Rojas

Abstract

Arsenic is carcinogen for humans and has been shown to act as an enhancer in initiated animal models. In a previous work we found impairment of lymphocyte proliferation in arsenic-exposed individuals and in vitro we obtained dose-related inhibition of mitotic response and lymphocyte proliferation. Intrigued by these effects and based on the role of p53 on cell proliferation, we tested different concentrations of sodium arsenite for their ability to induce the expression of tumor suppressor gene p53 in different cell lines (HeLa, C-33A. Jurkat) and a lymphoblast cell line transformed with Epstein-Barr virus (LCL-EBV). We also evaluated changes in their viability after 24 h arsenic treatment; C-33A cells showed the higher sensitivity to arsenic treatment while HeLa, Jurkat and LCL-EBV cells showed similar cytotoxicity curves. Immunoblots showed an increased expression of p53 gene with 1 microM sodium arsenite in Jurkat cells and 10 microM sodium arsenite in HeLa and LCL-EBV cells. In addition, we transfected Jurkat cells and human lymphocytes with wild-type and mutated p53 genes; lymphocytes and Jurkat cells that received the mutated p53 showed increased sensitivity to arsenic cytotoxicity. Data obtained indicate that arsenic ind...Continue Reading

References

Oct 1, 1992·Mutation Research·M E GonsebattP Ostrosky-Wegman
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ScheffnerP M Howley
Apr 1, 1991·Current Opinion in Cell Biology·J Milner
Jul 1, 1989·Biological Trace Element Research·J H Li, T G Rossman
Jul 1, 1988·Science·T C LeeJ C Barrett
Jan 1, 1985·Environmental Mutagenesis·D Jacobson-Kram, D Montalbano
Oct 1, 1994·Mutation Research·M E GonsebattP Ostrosky-Wegman
Feb 1, 1995·Current Opinion in Genetics & Development·R Haffner, M Oren
Mar 3, 1995·Science·S M CrossB J Reid
Jan 1, 1993·Annual Review of Biochemistry·A J Levine
Oct 28, 1993·The New England Journal of Medicine·C C Harris, M Hollstein
Jun 1, 1997·Mutation Research·M E GonsebattP Ostrosky-Wegman
Jun 1, 1997·Mutation Research·J W Yager, J K Wiencke

❮ Previous
Next ❯

Citations

Apr 15, 2010·Biological Trace Element Research·Zhi-Fang Wang, Xiong Guo
Jun 28, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J V Tapia-VieyraJ Mas-Oliva
Dec 4, 2003·Mutation Research·Toby G Rossman
Dec 4, 2003·Mutation Research·Marisa D Pulido, Alan R Parrish
Jul 28, 2004·Toxicology and Applied Pharmacology·Ari SchoenEric Dubé
Apr 6, 2002·Mutation Research·D MenéndezP Ostrosky-Wegman
Dec 3, 2002·Archives of Medical Research·Irene CorreaAngelina Quintero
Mar 30, 2002·Critical Reviews in Oncology/hematology·Ann M Bode, Zigang Dong
Aug 23, 2001·Mutation Research·F I AbdullaevJ J Espinosa-Aguirre
Jul 23, 1999·Mutation Research·E RojasP Ostrosky-Wegman
May 22, 2003·International Immunopharmacology·Georgina GaliciaRafael Saavedra
Mar 26, 2002·Journal of Toxicology and Environmental Health. Part a·I-Ching Ho, Te-Chang Lee
Apr 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·B Frazier TaylorJ Christopher States
Nov 12, 2002·Environmental Health Perspectives·Miroslav StýbloDavid J Thomas
Jul 6, 2005·The Tohoku Journal of Experimental Medicine·Mustafa YildirimErhan Varoglu
Feb 25, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yuanlin QiGang Chen
Feb 16, 2010·Toxicology and Applied Pharmacology·Alicia M BoltWalter T Klimecki
Mar 3, 2010·Toxicology and Applied Pharmacology·Daigo SumiYoshito Kumagai
Dec 2, 2008·Mutation Research·Ana María SalazarPatricia Ostrosky-Wegman
Oct 30, 2007·Blood Cells, Molecules & Diseases·Andrea Díaz-VillaseñorPatricia Ostrosky-Wegman
Apr 29, 2009·Cell Proliferation·Q DuanW Dai
Aug 1, 2008·Journal of Cellular Biochemistry·Yi-Chen WuLing-Huei Yih
Jun 25, 2009·Environmental and Molecular Mutagenesis·P Robinan GentryHarvey J Clewell
Apr 24, 2002·Toxicology and Applied Pharmacology·J Christopher StatesMichael J McCabe
Dec 14, 2004·Toxicology·A Hernández-ZavalaE Garrido
Aug 4, 2004·Free Radical Biology & Medicine·Honglian ShiKe Jian Liu
Apr 1, 2006·Mutation Research·Soile Tapio, Bernd Grosche
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ann Bode, Zigang Dong
Jul 4, 2008·Toxicology and Applied Pharmacology·Andrea Díaz-VillaseñorPatricia Ostrosky-Wegman
Oct 28, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jaspreet S SidhuElaine M Faustman
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zuzana DrobnáMiroslav Stýblo
Mar 18, 2017·Environmental Science and Pollution Research International·Carolina Di PaoloThomas-Benjamin Seiler
Oct 31, 2003·Toxicologic Pathology·Paul B TchounwouJose A Centeno
Mar 19, 2003·Chemical Research in Toxicology·Maria Filippova, Penelope J Duerksen-Hughes
Jan 29, 2020·Chemical Research in Toxicology·Lok Ming TamYinsheng Wang
Dec 13, 2003·Analytical Chemistry·Jue-Liang HsuShu-Hui Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved