Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS

The American Journal of Pathology
Eleanor RobertsH S Fox

Abstract

The etiology of the central nervous system (CNS) alterations after human immunodeficiency virus (HIV) infection, such as dementia and encephalitis, remains unknown. We have used microarray analysis in a monkey model of neuroAIDS to identify 98 genes, many previously unrecognized in lentiviral CNS pathogenesis, whose expression is significantly up-regulated in the frontal lobe of simian immunodeficiency virus-infected brains. Further, through immunohistochemical illumination, distinct classes of genes were found whose protein products localized to infiltrating macrophages, endothelial cells and resident glia, such as CD163, Glut5, and ISG15. In addition we found proteins induced in cortical neurons (ie, cyclin D3, tissue transglutaminase, alpha1-antichymotrypsin, and STAT1), which have not previously been described as participating in simian immunodeficiency virus or HIV-related CNS pathology. This molecular phenotyping in the infected brains revealed pathways promoting entry of macrophages into the brain and their subsequent detrimental effects on neurons. These data support the hypothesis that in HIV-induced CNS disease products of activated macrophages and astrocytes lead to CNS dysfunction by directly damaging neurons, as we...Continue Reading

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Citations

Jan 11, 2005·Neurotoxicity Research·Huanyu DouHoward E Gendelman
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Clarisa M BucknerJoan W Berman
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Gurudutt PendyalaHoward S Fox
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yuri Persidsky, Howard Fox
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joan W BermanWalter Royal
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Howard E Gendelman
Aug 22, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Alejandra BorjabadDavid J Volsky
Sep 17, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sowmya V Yelamanchili, Howard S Fox
Mar 1, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica M WinklerHoward S Fox
Jun 8, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rebeca GeffinMicheline McCarthy
May 24, 2005·Brain Research. Molecular Brain Research·Yoshiko FuriyaSatoshi Ueno
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Harris A GelbardHoward E Gendelman
Aug 4, 2010·Journal of Proteome Research·Jayme L WiederinPawel S Ciborowski
Mar 14, 2009·Journal of Proteome Research·Gurudutt PendyalaHoward S Fox
Apr 5, 2005·Nature Reviews. Microbiology·Richard G Jenner, Richard A Young
Jun 17, 2008·Nature Reviews. Microbiology·Hal Drakesmith, Andrew Prentice
Sep 10, 2008·Journal of Neurovirology·Howard S Fox
Jul 12, 2008·The Journal of Infectious Diseases·Tricia H BurdoHoward S Fox
Oct 12, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Luna Alammar ZaritskyJanice E Clements
Sep 27, 2005·AIDS·Tricia H BurdoHoward S Fox
Jun 16, 2005·Journal of Virology·Jianping Wang, Iain L Campbell
Apr 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·Veronique Douard, Ronaldo P Ferraris
Mar 14, 2013·BioMed Research International·Maria Cecilia Garibaldi MarcondesHoward Fox
Aug 31, 2013·Retrovirology·Jeanne M SiskJanice E Clements
Mar 21, 2007·Journal of Leukocyte Biology·Tricia H BurdoHoward S Fox
Oct 11, 2012·PloS One·Benjamin B GelmanUNKNOWN National NeuroAIDS Tissue Consortium
Oct 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Merril GerstenHoward S Fox
Aug 27, 2013·Critical Reviews in Immunology·Alexander J Gill, Dennis L Kolson
Sep 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Salvador Huitron-ResendizHoward S Fox

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