Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans

Fertility and Sterility
Sakhila K BanuJoe A Arosh

Abstract

To determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice. Prospective experimental study. Human immortalized endometriosis epithelial and stromal cells were xenografted into ovariectomized nude mice. Macroscopically, the number of induced endometriosis-like lesions and their color were determined. Microscopically, histomorphology of endometriosis glands and their structure were analyzed, and comparisons were made with tissue from spontaneous endometriosis in women. College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. Seven ovariectomized nude mice. Minimal invasive procedures were performed to administer estrogen pellets and transplant immortalized human endometriosis epithelial and stromal cells into nude mice. Peritoneal endometriosis-like lesions induced in nude mice were characterized and compared with spontaneous peritoneal endometriosis in women. Xenografts of human immortalized endometriosis epithelial and stromal cells into the peritoneal cavity of the recipient nude mice are able to proliferate, attach, invade, reorganize, and establish peritoneal endometriosis. Endometriosis glands at differ...Continue Reading

References

Jul 1, 1992·Acta Obstetricia Et Gynecologica Scandinavica·M H Moen, T B Halvorsen
Feb 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A BergqvistO Ljungberg
Jul 15, 1984·American Journal of Obstetrics and Gynecology·N M ZamahR H Kaufman
Aug 12, 1994·Journal of Molecular Biology·T S KrishnaJ Kuriyan
Mar 20, 1998·European Journal of Endocrinology·Y KatsukiS Nozawa
Aug 4, 1998·Human Reproduction·J DonnezM Nisolle
Feb 23, 1999·Human Reproduction Update·A Starzinski-PowitzR Baumann
Dec 22, 1999·Human Reproduction·J T AwwadK Isaacson
Dec 28, 1999·Human Reproduction·I A Brosens, J J Brosens
Jun 16, 2001·American Journal of Obstetrics and Gynecology·A J WalterJ F Magrina
Feb 28, 2002·Human Reproduction Update·Thomas M D'Hooghe, Sophie Debrock
Mar 20, 2002·Current Molecular Medicine·A Starzinski-PowitzR Baumann
Apr 13, 2002·Annals of the New York Academy of Sciences·Serdar E BulunSiby Sebastian
Oct 10, 2002·Fertility and Sterility·Pamela StrattonLynnette K Nieman
Apr 18, 2003·Obstetrics and Gynecology Clinics of North America·Thomas M D'HoogheJason M Mwenda
Jun 28, 2003·Journal of Cell Science·Giovanni Maga, Ulrich Hubscher
Aug 15, 2003·Seminars in Reproductive Medicine·Julie M Hastings, Asgerally T Fazleabas
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Annemiek W NapPatrick G Groothuis
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Lynne Chang, Robert D Goldman
Nov 16, 2004·Lancet·Linda C Giudice, Lee C Kao
Jan 18, 2005·Fertility and Sterility·Jason A EfstathiouMaria A Rupnick
Jul 13, 2005·Fertility and Sterility·Kevin G OsteenEsther Eisenberg
Aug 9, 2005·Fertility and Sterility·Julie EggermontAnne Van Langendonckt
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Janos GaraiJozsef Bodis
Jan 18, 2007·Expert Reviews in Molecular Medicine·Meng-Hsing WuShaw-Jenq Tsai
Jan 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hirotaka MasudaYasunori Yoshimura
Feb 3, 2007·BMJ : British Medical Journal·Cynthia Farquhar
Mar 10, 2007·Human Reproduction Update·Matthias W Laschke, Michael D Menger

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Citations

Nov 19, 2011·Human Reproduction·C G T SilveiraA Agic
Jul 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Joe A AroshSakhila K Banu
Apr 24, 2012·Fertility and Sterility·Diana MonsivaisSerdar E Bulun
Jan 9, 2010·Fertility and Sterility·Daniel Escorsim MachadoLuiz Eurico Nasciutti
Feb 8, 2014·Journal of Ovarian Research·Doerthe BrueggmannKate Lawrenson
Jun 28, 2014·Gynecologic Oncology·Kate LawrensonSimon A Gayther
Feb 25, 2017·Acta Obstetricia Et Gynecologica Scandinavica·Erin GreavesPhilippa T K Saunders
Jan 30, 2015·Acta Cirúrgica Brasileira·Francisco Edson Ximenes Gomes PereiraFrancisco das Chagas Medeiros
Nov 2, 2011·Acta Cirúrgica Brasileira·João Nogueira NetoEduardo Schor
Nov 6, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Tiinçe AksakSait Polat

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