PMID: 7010135Jan 1, 1981Paper

Induction of petite "mutants" in an ethidium-resistant strain of Saccharomyces cerevisiae by photoaffinity labeling. Distinction between early and late steps

Mutation Research
M Fukunaga, K L Yielding

Abstract

A strain of Saccharomyces cerevisiae (MH41-7B/011) was resistant to petite induction by ethidium bromide at 30 degrees, but was sensitive to induction by photolabeling with ethidium monoazide. These results suggested a defect in the mutant in metabolic activation of ethidium to account for its resistance. Synchronized cultures of both the mutant and the normal parent strains showed a substantial reduction in petite response to photolabeling in stationary phase cells which could not be accounted for by changes in cell penetration of the drug. The use of photolabeling with normal and mutant cells suggested that petite induction can be divided into early and late steps.

References

Sep 29, 1978·Biochemical and Biophysical Research Communications·M Fukunaga, K L Yielding
Jan 16, 1979·Molecular & General Genetics : MGG·S C HixonR L Irons
Jun 12, 1979·Biochimica Et Biophysica Acta·M Fukunaga, K L Yielding
Mar 22, 1976·Biochemical and Biophysical Research Communications·R de Nobrega, H R Mahler
Nov 2, 1977·Biochimica Et Biophysica Acta·D E GravesK L Yielding
Aug 4, 1975·Biochemical and Biophysical Research Communications·L WheelisR S Criddle
Jun 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H R Mahler, R N Bastos
Jan 1, 1972·Archives of Biochemistry and Biophysics·H R Mahler, P S Perlman
Jan 1, 1972·Journal of Supramolecular Structure·H R Mahler, P S Perlman
Feb 1, 1974·FEBS Letters·H R Mahler, R N Bastos
Dec 3, 1971·Biochemical and Biophysical Research Communications·C P Hollenberg, P Borst
Jul 16, 1971·Biochemical and Biophysical Research Communications·P S Perlman, H R Mahler

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Citations

Oct 10, 1998·Biochimica Et Biophysica Acta·F LengJ B Chaires
Jun 1, 1984·Biopolymers·G L CoffmanL Yielding

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