PMID: 15222400Jun 30, 2004Paper

Induction of preneoplastic altered hepatic foci following dietary sulphur supplementation

Human & Experimental Toxicology
Annu Arora, Yogeshwer Shukla

Abstract

Sulphur is an essential micronutrient required by the body in low concentrations, but its high intake can lead to a serious health hazard. Sulphur compounds are reported to induce several toxic responses in animals, but so far no reports are available on the toxic effects of elemental sulphur, following dietary supplementation. The present investigation was carried out with the aim of providing an insight into the role of dietary supplementation of sulphur on the induction of altered hepatic foci (AHF) using medium term liver bioassay in Wistar rats. Induction of AHF are early neoplastic changes in rat liver in diethylnitrosamine (DEN)-initiated and 2-acetylaminofluorene (2-AAF)-promoted hepatocarcinogenesis. The role of sulphur on induction of AHF was evaluated by the development of negative enzymatic foci for alkaline phosphatase (AlkPase), adenosine triphosphatase (ATPase), glucose-6-phosphatase (G-6-Pase) and positive foci for marker enzymes, gamma-glutamyl transferase (GGT), placental isozyme of glutathione-S-transferase (GST-P). A significant dose-dependent decrease in the relative and absolute liver weight of sulphur-administered rats was recorded. Dietary supplementation of 2% and 4% sulphur significantly induces both n...Continue Reading

References

Nov 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Hasegawa, N Ito
Jan 1, 1989·Critical Reviews in Toxicology·N ItoH Tsuda
Feb 1, 1971·Journal of Animal Science·H J Weeth, J E Hunter
Jan 1, 2003·Nutrition·Lioudmila A KomarniskyTapan K Basu
Jun 7, 2003·Nutrition and Cancer·Yogeshwer Shukla, Annu Arora
Jun 1, 1946·American Journal of Clinical Pathology·G GOMORI

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Citations

Dec 6, 2008·Investigational New Drugs·Smita SrivastavaYogeshwer Shukla

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