Induction of prolonged tenderness in patients with tension-type headache by means of a new experimental model of myofascial pain

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
H MørkR Jensen

Abstract

Tenderness is the most prominent abnormal finding in patients with tension-type headache (TTH). Recently we developed a model of myofascial tenderness using intramuscular infusion of a combination of bradykinin, serotonin, histamine and prostaglandin E2. We aimed to examine tenderness after this combination in patients with episodic TTH (ETTH). Fifteen patients and 15 healthy controls completed the study. Participants received the combination into the non-dominant trapezius muscle in a randomized, double-blinded and placebo-controlled design. Local tenderness and stimulus-response functions, mechanical pain thresholds (PPDT) in the temporal region and on the finger, and total tenderness score (TTS) were recorded. A local, prolonged, and mild to moderate tenderness was reported both in patients (P = 0.001) and in controls (P = 0.001) after the combination compared with the placebo. The response to the combination tended to be increased in patients. The stimulus-response function was leftward shifted after the combination, compared with baseline in both groups. No changes in PPDT or TTS were found after the infusions, whereas baseline PPDTs were decreased in ETTH compared with controls (PPDTfinger: P = 0.033; PPDTtemporal: P = 0....Continue Reading

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Citations

Nov 8, 2003·Current Pain and Headache Reports·Lars Bendtsen
Nov 12, 2005·Current Pain and Headache Reports·Sait AshinaMessoud Ashina
Jul 8, 2011·Current Pain and Headache Reports·Lars Bendtsen, César Fernández-de-la-Peñas
Jun 17, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S AshinaL Bendtsen
Oct 20, 2005·Cephalalgia : an International Journal of Headache·M B ChristensenR Jensen
May 12, 2006·Cephalalgia : an International Journal of Headache·A MakowskaJ Ellrich
Mar 16, 2007·Cephalalgia : an International Journal of Headache·C Fernández-de-las-PeñasJ A Pareja
Jun 21, 2013·Journal of Pain Research·Ann-Britt L SoeeLise L Thomsen
Aug 21, 2013·Expert Review of Neurotherapeutics·Marina de Tommaso, Eleonora Vecchio
Apr 16, 2009·The Journal of Headache and Pain·Barbara Gierse-PlogmeierStefan Evers
Mar 18, 2009·Neurologic Clinics·Lars Bendtsen, Rigmor Jensen
Dec 21, 2007·Lancet Neurology·Arnaud Fumal, Jean Schoenen
Aug 22, 2006·European Journal of Pain : EJP·César Fernández-de-Las-PeñasJuan A Pareja
Oct 30, 2010·Headache·David BezovLars Bendtsen
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·T Graven-Nielsen
Dec 13, 2006·Pain·Peter T Schmidt-HansenFlemming W Bach
May 3, 2005·European Journal of Pain : EJP·Messoud AshinaRigmor Jensen
Feb 23, 2017·Pain Practice : the Official Journal of World Institute of Pain·María Palacios CeñaCésar Fernández-de-Las-Peñas
Jun 28, 2013·Cephalalgia : an International Journal of Headache·Jacques AbboudMartin Descarreaux
Jan 22, 2005·Cephalalgia : an International Journal of Headache·A MakowskaJ Ellrich
Aug 18, 2010·Cephalalgia : an International Journal of Headache·Lars Bendtsen
Nov 19, 2009·The Clinical Journal of Pain·Sureeporn UthaikhupGwendolen Jull
May 19, 2021·Neurology India·Sanjeev Kumar BhoiDebashish Chowdhury

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