Induction of protection in murine experimental models against Trichinella spiralis: an up-to-date review

Journal of Helminthology
G Ortega-PierresR Argüello-García

Abstract

The parasitic nematode Trichinella spiralis, an aetiological agent of the disease known as trichinellosis, infects wild and domestic animals through contaminated pig meat, which is the major source for Trichinella transmission. Prevention of this disease by interrupting parasite transmission includes vaccine development for livestock; however, major challenges to this strategy are the complexity of the T. spiralis life cycle, diversity of stage-specific antigens, immune-evasion strategies and the modulatory effect of host responses. Different approaches have been taken to induce protective immune responses by T. spiralis immunogens. These include the use of whole extracts or excretory-secretory antigens, as well as recombinant proteins or synthesized epitopes, using murine experimental models for trichinellosis. Here these schemes are reviewed and discussed, and new proposals envisioned to block the zoonotic transmission of this parasite.

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Citations

Jul 9, 2016·Veterinary Parasitology·Jing YangXinping Zhu
Jul 12, 2016·Veterinary Parasitology·Rosa Ma Bermúdez-CruzM Guadalupe Ortega-Pierres
Jun 7, 2018·Transboundary and Emerging Diseases·Nianzhang ZhangBaoquan Fu
Apr 19, 2018·Journal of Veterinary Medicine·Abadi Amare Reda
Sep 30, 2020·Veterinary Research·Xin YueZhong Quan Wang
Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Valeria A SanderMarina Clemente

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