Induction of protective CTL responses in newborn mice by a murine retrovirus

Science
M SarzottiP M Hoffman

Abstract

The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

References

Feb 1, 1975·The Australian Journal of Experimental Biology and Medical Science·K J Lafferty, A J Cunningham
Nov 13, 1992·Science·E J Fuchs, P Matzinger
Jan 1, 1991·Journal of Neuroimmunology·D S Robbins, P M Hoffman
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B D Jamieson, R Ahmed
Dec 1, 1970·Virology·W P RoweJ W Hartley
Oct 1, 1973·Journal of the National Cancer Institute·M B GardnerR J Huebner
Feb 1, 1974·The Journal of Experimental Medicine·P G Spear, G M Edelman
Sep 1, 1981·The Journal of Experimental Medicine·P F PiguetP Vassalli
Sep 1, 1984·The Journal of Experimental Medicine·A E LukacherT J Braciale
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C Y LuE R Unanue
Nov 1, 1995·Journal of Virology·D S RobbinsP M Hoffman
Apr 15, 1995·Transplantation·N Chen, E H Field
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J K ActorJ A Berzofsky

❮ Previous
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Citations

Feb 5, 1999·European Journal of Immunology·B P ArulanandamD W Metzger
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·R M Zinkernagel
May 26, 2001·Bulletin of Mathematical Biology·C BergmannL A Segel
Jan 1, 1997·Springer Seminars in Immunopathology·C A Siegrist, P H Lambert
Jan 1, 1997·Springer Seminars in Immunopathology·D M KlinmanJ Conover
Jan 1, 1997·Springer Seminars in Immunopathology·Z Q XiangH C Ertl
Apr 11, 2006·Japanese Journal of Ophthalmology·Fatih FatoohiFrançois Peyron
Apr 27, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Lauren A O'Donnell, Glenn F Rall
Jun 1, 1996·Immunology Today·B Stockinger
Dec 5, 1998·Transplantation Proceedings·J SunR Sheil
Mar 16, 2000·Developmental and Comparative Immunology·A R Jilbert, I Kotlarski
Jun 20, 2002·Veterinary Immunology and Immunopathology·Otti BengtssonKjell-Olov Grönvik
Jun 20, 2002·Veterinary Immunology and Immunopathology·Bror MoreinGunilla Blomqvist
Mar 12, 2003·Veterinary Immunology and Immunopathology·N K BoydJ M Ball
Jun 4, 1999·Immunology Today·S M MontgomeryA J Wakefield
Jun 24, 1999·Immunology Today·B Adkins
Jan 19, 2000·Immunology Today·S Marshall-ClarkeJ Hassan
Apr 18, 2003·Archives of Medical Research·Arturo Cérbulo-VázquezLeopoldo Santos-Argumedo
Feb 1, 1997·Human Immunology·L Brent
Feb 1, 1997·Human Immunology·K J Lafferty, L S Gazda
Jan 23, 1998·Human Immunology·H N TrivediF A Plummer
May 12, 2001·Vaccine·C A Siegrist
Aug 26, 1998·Vaccine·C ButtsM Sarzotti
Dec 1, 1996·Current Opinion in Immunology·J F Miller, A Basten
Nov 14, 1997·Trends in Microbiology·H Bielefeldt-Ohmann
Nov 13, 2008·Cytotechnology·M HashiguchiS Kaminogawa
Mar 4, 2000·Allergy·C A JonesJ O Warner
Nov 2, 2004·Nature Medicine·Jagdeep S Obhrai, Fadi G Lakkis
Jul 2, 2004·Nature Reviews. Immunology·Becky AdkinsStuart Marshall-Clarke

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