PMID: 8596933DOI: 10.1126/science.271.5256.1726Mar 22, 1996Paper
Induction of protective CTL responses in newborn mice by a murine retrovirus
Science
M SarzottiP M Hoffman
Abstract
The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.
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