Induction of protective immunity against Eimeria tenella, Eimeria maxima, and Eimeria acervulina infections using dendritic cell-derived exosomes.

Infection and Immunity
Emilio Del CachoCaridad Sánchez-Acedo

Abstract

This study describes a novel immunization strategy against avian coccidiosis using exosomes derived from Eimeria parasite antigen (Ag)-loaded dendritic cells (DCs). Chicken intestinal DCs were isolated and pulsed in vitro with a mixture of sporozoite-extracted Ags from Eimeria tenella, E. maxima, and E. acervulina, and the cell-derived exosomes were isolated. Chickens were nonimmunized or immunized intramuscularly with exosomes and subsequently noninfected or coinfected with E. tenella, E. maxima, and E. acervulina oocysts. Immune parameters compared among the nonimmunized/noninfected, nonimmunized/infected, and immunized/infected groups were the numbers of cells secreting T(h)1 cytokines, T(h)2 cytokines, interleukin-16 (IL-16), and Ag-reactive antibodies in vitro and in vivo readouts of protective immunity against Eimeria infection. Cecal tonsils, Peyer's patches, and spleens of immunized and infected chickens had increased numbers of cells secreting the IL-16 and the T(h)1 cytokines IL-2 and gamma interferon, greater Ag-stimulated proliferative responses, and higher numbers of Ag-reactive IgG- and IgA-producing cells following in vitro stimulation with the sporozoite Ags compared with the nonimmunized/noninfected and nonimmu...Continue Reading

References

Dec 1, 1987·Veterinary Immunology and Immunopathology·M E Rose
Dec 1, 1993·The Anatomical Record·E del CachoA Zapata
Feb 9, 1999·Veterinary Parasitology·R GargS K Gupta
Mar 14, 2000·Veterinary Immunology and Immunopathology·C H YunK D Choi
Mar 16, 2000·Developmental and Comparative Immunology·C H YunE P Lillehoj
Dec 21, 2000·Parasite Immunology·V McDonald
Feb 13, 2001·Cellular Immunology·C B LópezT M Moran
Apr 5, 2001·International Journal for Parasitology·P C Augustine
Apr 9, 2002·Preventive Veterinary Medicine·Mohammad Q Al-NatourMahmoud N Abo-Shehada
Sep 24, 2002·Seminars in Cell & Developmental Biology·Jean-Luc MurkHans J Geuze
Nov 12, 2002·Nature Immunology·Clotilde ThérySebastian Amigorena
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J J De BieA J M Van Oosterhout
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth A LynchWilliam W Cruikshank
Mar 26, 2004·Vaccine·Silvia BozzaLuigina Romani
Feb 3, 2006·Expert Review of Vaccines·Rami A Dalloul, Hyun S Lillehoj
Mar 3, 2006·Experimental Parasitology·Alireza Talebi, Grace Mulcahy
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Xiao-Bo LiShun-Qing Xu
Jul 20, 2006·Current Cancer Drug Targets·L MieleB J Nickoloff
Aug 22, 2006·Experimental Parasitology·Humphrey N EhigiatorJan R Mead
Sep 26, 2006·Veterinary Immunology and Immunopathology·Yeong Ho HongErik P Lillehoj
Aug 21, 2007·European Journal of Immunology·Katharina A RemerHeidrun Moll
Nov 1, 2007·European Journal of Immunology·Ralph M Steinman
Apr 1, 2008·Journal of Immunological Methods·Emilio Del CachoHyun S Lillehoj
Oct 15, 2008·PloS One·Venkateswara Rao SimhadriElke Pogge von Strandmann
Jan 31, 2009·Veterinary Immunology and Immunopathology·Emilio Del CachoCaridad Sánchez-Acedo
Aug 6, 2010·Experimental Parasitology·Franz PetryTesfaye S Tessema
Dec 1, 2010·International Journal of Nanomedicine·Aaron TanAlexander M Seifalian
Feb 22, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Sung Hyen LeeWongi Min

❮ Previous
Next ❯

Citations

Dec 4, 2013·Immunology Letters·Brahmchetna BediJan R Mead
Oct 5, 2015·Trends in Parasitology·Gillian CoakleyAmy H Buck
Mar 26, 2013·Proteomics·Jake CosmeAnthony O Gramolini
Sep 18, 2015·Journal of Immunology Research·João Henrique CamposAna Claudia Torrecilhas
Apr 16, 2013·Developmental and Comparative Immunology·Wongi MinHyun S Lillehoj
Sep 25, 2014·Frontiers in Immunology·Sergio MontanerAntonio Marcilla
May 31, 2016·Developmental and Comparative Immunology·Angelica Van GoorSusan J Lamont
Jun 9, 2016·Veterinary Parasitology·Emilio Del CachoCaridad Sánchez-Acedo
Apr 5, 2014·Journal of the American Society of Nephrology : JASN·Thomas F HiemstraFiona E Karet Frankl
May 11, 2018·Parasite Immunology·R K ShearsD J Thornton
Jun 13, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Leticia Gomes de PontesLucilene Delazari Dos Santos
Jan 13, 2019·International Journal of Molecular Sciences·Claudia CampanellaStefano Fais
Jan 31, 2019·Frontiers in Immunology·Zhenyu WuXi Sun
Feb 19, 2021·Molecular Immunology·Izadora Volpato RossiMarcel Ivan Ramirez
Jul 3, 2021·International Journal of Molecular Sciences·Mahmoud ElashiryChristopher W Cutler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.