Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin.

Infection and Immunity
J P DaltonS J Andrews

Abstract

Two cathepsin L proteinases, cathepsin L1 and cathepsin L2, secreted by liver flukes may be involved in tissue penetration, nutrition, and protection from immune attack. To ascertain the immunoprophylactic potential of these proteinases, and of another molecule, liver fluke hemoglobin (Hb), we performed vaccine trials in cattle. In the first vaccine trial various doses of cathepsin L1 were tested. The mean protection level obtained was 53.7%. In a second vaccine trial cathepsin L1 and Hb elicited 42.5 and 43.8% protection levels, respectively, while a combination of the two molecules induced a significantly higher level of protection (51.9%). Cathepsin L2 was not examined alone; however, vaccination of cattle with a combination of cathepsin L2 and Hb elicited the highest level of protection (72.4%). The animals that received cathepsin L1-Hb or cathepsin L2-Hb showed reduced liver damage as assessed by serum glutamic dehydrogenase and gamma-glutamyl transferase levels. Furthermore, a reduced viability was observed for fluke eggs recovered from all vaccine groups. This anti-embryonation effect of vaccination was particularly evident in the group that received cathepsin L2-Hb where >98% of the eggs recovered did not embryonate to ...Continue Reading

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Citations

Jan 24, 2006·Infection and Immunity·Michael S DuffyJudith A Appleton
Jun 6, 2012·PLoS Neglected Tropical Diseases·E James LaCoursePeter M Brophy
Jun 9, 2020·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Alaa H A HegazyRefaat M A Khalifa
Oct 2, 2013·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·S MandalS Jana
Sep 11, 2004·The Journal of Parasitology·Ana M Espino, George V Hillyer
Nov 30, 2000·Current Infectious Disease Reports·T R Hawn, E C Jong
Mar 1, 2006·Indian Journal of Clinical Biochemistry : IJCB·Y P BhandaryB C Harinath
Sep 7, 2013·PLoS Neglected Tropical Diseases·Natalie E NieuwenhuizenAndreas L Lopata
Jun 2, 2012·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·R L SharmaM B Thilagar
Jan 23, 2018·Expert Review of Vaccines·Gebeyaw Getnet MekonnenJavier Sotillo
Jan 24, 2007·Infection and Immunity·Amit KumarVirander Singh Chauhan

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