Induction of protein droplet (alpha 2 mu-globulin) nephropathy in male rats after short-term dosage with 1,8-cineole and l-limonene

Toxicology Letters
E Kristiansen, C Madsen

Abstract

As part of a series of short-term studies on peppermint oil constituents for their possible induction of the encephalopathy found with peppermint oil, 1,8-cineole and l-limonene were studied. Groups of 10 male Wistar rats were given 0, 500, or 1000 mg 1,8-cineole/kg body wt./day or 0, 800, or 1600 mg l-limonene/kg body wt./day for 28 days. 1,8-Cineole and l-limonene both induced accumulation of protein droplets containing alpha 2 mu-globulin in proximal tubular epithelial cells in male rats. These results suggest that both 1,8-cineole and l-limonene possibly belong to the group of chemicals characterized by their induction of excessive alpha 2 mu-globulin accumulation. Neither of the 2 substances induced encephalopathy.

References

Sep 1, 1992·Toxicology Letters·P Spindler, C Madsen
Jan 1, 1989·Toxicology and Applied Pharmacology·J A SwenbergM Charbonneau
Jul 1, 1986·Toxicology Letters·C MadsenJ Carstensen
Dec 1, 1983·Toxicology Letters·I ThorupP Olsen
Dec 1, 1983·Toxicology Letters·I ThorupP Olsen

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Citations

Jun 13, 2006·Phytotherapy Research : PTR·Diane L McKay, Jeffrey B Blumberg
Jun 19, 2017·BMC Veterinary Research·Xuerong ZhouCheng Lv
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Majid TafrihiRaffaele Pezzani
Jul 5, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gerhard EisenbrandSean V Taylor
Aug 11, 2021·Plants·Katarine F SilvaCelso Caruso-Neves

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