PMID: 9541461Apr 16, 1998Paper

Induction of pulmonary immunity in cattle by oral administration of ovalbumin in alginate microspheres

Immunology Letters
T L BowersockK Park

Abstract

Respiratory infectious diseases are an important cause of economic losses to the cattle industry. There is a need for an effective, easy to administer vaccine to the critical bacterial pathogens that cause pneumonia in cattle. An orally administered vaccine could be given to a large number of animals without significant stress to the animals and with minimal labor. The purpose of this study was to determine whether the oral administration of a model antigen (ovalbumin) in alginate microspheres could induce pulmonary immunity in cattle. Calves were vaccinated orally with ovalbumin (OVA) following either a subcutaneous (s.c.) or oral priming dose of OVA. Calves primed and boostered by oral administration (oral/oral) of OVA encapsulated in alginate microparticles had increased numbers of antigen-specific IgA ASCs (ASCs) in bronchoalveolar lavage (BAL) fluids. Calves that received a s.c. priming followed by an oral booster inoculation (s.c./oral) of OVA in alginate microspheres had a greater number of anti-OVA IgA, IgG1 and IgG2 ASCs in BALF. S.c./oral calves also had increased numbers of anti-OVA IgG1 ASCs in peripheral blood whereas oral/oral calves had none. S.c./oral calves had increased anti-OVA IgG1, IgG2, and IgA titers in B...Continue Reading

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Citations

Aug 23, 2001·Journal of Immunological Methods·V GerdtsP J Griebel
Oct 19, 2002·Journal of Reproductive Immunology·Shari Lofthouse, Joanna Kemp
Dec 14, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·B KimG K Mutwiri
Apr 1, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·S BabiukM Foldvari
Oct 5, 2002·Advanced Drug Delivery Reviews·Shari Lofthouse
Jun 6, 2000·Advanced Drug Delivery Reviews·T L Bowersock, S Martin
Dec 21, 2010·Archives of Virology·Peter M H HeegaardNanna Skall Sørensen
Nov 22, 2005·Expert Opinion on Drug Delivery·George MutwiriLorne A Babiuk
Jun 5, 2007·Veterinary Immunology and Immunopathology·Tom N McNeillyJohn F Huntley
Dec 12, 2012·Vaccine·Volker GerdtsAndrew A Potter
Oct 10, 2006·Journal of Biomaterials Science. Polymer Edition·M TafaghodiM R Jaafari
Apr 14, 2006·Veterinary Research·Volker GerdtsLorne A Babiuk
Nov 21, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Preeti KourAmit Kumar Goyal
Dec 24, 2008·Animal Health Research Reviews·Andrew PotterSylvia van Drunen Littel-van den Hurk
Jan 25, 2019·Gels·Víctor H Pérez-Luna, Orfil González-Reynoso
Jun 22, 2021·Expert Opinion on Drug Delivery·Pedro Gonzalez-Cruz, Harvinder Singh Gill
Jun 22, 2021·Frontiers in Pharmacology·Seyed Davoud JazayeriChit Laa Poh

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