PMID: 8946767Jan 1, 1996Paper

Induction of radio-adaptive response by low-dose X-irradiation on chromosome aberrations in human embryonic fibroblasts

Physiological Chemistry and Physics and Medical NMR
K Ishii, J Misonoh

Abstract

Inonizing radiation induces mutation and chromosome aberrations in the irradiated cells. However, the frequency of chromosome aberrations induced by high-dose X-ray irradiation is diminished in cells exposed to low-dose pre-irradiation. The radio-adaptive response induced by low-dose radiation has been previously reported. These studies usually choose V79 cells or human peripheral lymphocytes as test materials. However, V79 cells are no longer normal diploid cells and in the case of human peripheral lymphocytes, artificial blastoid transformation by a mitogen is necessary for the experiments. In order to observe the radio-adaptive response of normal cells under natural conditions, we elected to study human embryonic fibroblasts as cells in the normal cell cycle under natural conditions. We investigated the dose dependency of the frequency of chromosome aberrations induced by radiation, conditions required to induce the radio-adaptive response, and the relationship between radio-adaptive response and protein production system. As a result, the number of chromosome aberrations significantly increased with high dose irradiation as a function of dose. When a conditioning irradiation of 10 cGy was given to cells 4 hours before the i...Continue Reading

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