Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M A WalligE H Jefferey

Abstract

The chemoprotective effects of cruciferous vegetables against cancer has been linked to the induction of detoxification enzymes, including the phase II enzymes, glutathione S-transferases (GST) and quinone reductase (QR). Four glucosinolate breakdown products found in Brussels sprouts and previously shown individually to affect detoxification enzymes--(1-cyano-2-hydroxy-3-butene (Crambene), indole-3-carbinol (I3C), phenylethyl isothiocyanate (PEITC) and 1-isothiocyanato-3-(methylsulfinyl)-propane (IBN) were administered to male F344 rats by oesophageal intubation for 7 days both as a mixture and individually to assess the effect of these compounds on GST and QR activity in the pancreas, an organ previously shown to be affected by cruciferous diets. The doses of each compound in the mixture (50 mg Crambene/kg, 56 mg I3C/kg, 0.1 mg PEITC/kg and 38 mg IBN/kg) were chosen to represent the relative proportions of the parent glucosinolate for each compound in Brussels sprouts and shown to be below the toxic threshold for all the compounds. In rats receiving the mixture, pancreatic QR and GST activities were elevated 31- and 1.7-fold, respectively, while glutathione (GSH) was elevated threefold. On an individual basis, Crambene alone ...Continue Reading

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