PMID: 590684Oct 1, 1977

Induction of rectal carcinoma in mice by local x-irradiation

Gann = Gan
F HiroseS Otsuka


The pelvic region of random bred female ICR-JCL mice and CF1 mice was irradiated with various doses of X-rays at 1-week intervals to determine the relationship between the X-ray dose and induction of rectal carcinoma. The incidence of rectal carcinoma in ICR mice was zero after a single dose of 2,000 rad of X-rays, but 31% after a single dose of 3,000 rad, 6% after 2 doses of 1,500 rad, 25% after 3 doses of 1,500 rad, 42% after 2 doses of 2,000 rad, and 95% after 3 doses of 2,000 rad. This cancer developed in 70% of CF1 mice exposed to 2 doses of 2,000 rad. No case of this tumor was observed in the control animals not exposed to X-rays. The development of this tumor was found to depend on the X-ray exposure dose. Local X-irradiation of the pelvic region is one of the effective methods for inducing rectal carcinoma in mice. Rectal cancers induced by X-irradiation were adenocarcinoma of the tubular, papillary, and mucinous type, and frequently showed invasive growth into the deep layers of the rectal wall.

Related Concepts

Carcinoma, Cribriform
Squamous Cell Carcinoma
Dose-Response Relationship, Radiation
Structure of Intestinal Gland
Neoplasms, Experimental
Radiation-Induced Cancer
Hereditary Diffuse Gastric Cancer
Roentgen Rays

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