Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

Autoimmunity Reviews
Mitesh DwivediE Helen Kemp

Abstract

Regulatory T cells (Tregs) are comprised of a heterogeneous population of cells that play a vital role in suppressing inflammation and maintaining immune tolerance. Given the crucial role of Tregs in maintaining immune homeostasis, it is probably not surprising that many microbial species and their metabolites have the potential to induce Tregs. There is now great interest in the therapeutic potential of probiotics and prebiotics based strategies for a range of autoimmune disorders. This review will summarise recent findings concerning the role of probiotics and prebiotics in induction of Tregs to ameliorate the autoimmune conditions. In addition, the article is focused to explain the different mechanisms of Treg induction and function by these probiotics and prebiotics, based on the available studies till date. The article further proposes that induction of Tregs by probiotics and prebiotics could lead to the development of new therapeutic approach towards curbing the autoimmune response and as an alternative to detrimental immunosuppressive drugs.

References

Oct 1, 1991·Immunology Today·R P PhippsR L Roper
May 1, 1989·The Journal of Applied Bacteriology·R Fuller
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·J G GribbenG S Gray
Feb 1, 1997·The American Journal of the Medical Sciences·J G WheelerR M Helm
Jan 31, 2003·European Journal of Clinical Nutrition·G PerdigónM Medici
Dec 25, 2003·International Journal of Dermatology·Juraj HegyiVladimír Hegyi
Feb 12, 2004·Scandinavian Journal of Immunology·M-F LiuC-R Wu
May 25, 2004·Infection and Immunity·Maureen DrakesSteven Czinn
Jun 1, 2004·Inflammatory Bowel Diseases·Thomas MenzelWolfgang Scheppach
Jun 3, 2004·Nature Reviews. Immunology·Andrew J Macpherson, Nicola L Harris
Oct 7, 2004·International Immunology·Haruhiko YagiShimon Sakaguchi
Oct 16, 2004·Immunity·Ching-Tai HuangDario A A Vignali
Nov 17, 2004·The Journal of Clinical Investigation·Anne O'GarraAnne E Goldfeld
Jan 5, 2005·The Journal of Experimental Medicine·Shuang LiangMichele M Kosiewicz
Mar 24, 2005·Nature Immunology·Ronald H Schwartz
Nov 18, 2005·Gene·Michele A GlozakEdward Seto
Nov 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L E M NiersM O Hoekstra
Feb 16, 2006·Immunology·Christian DejacoMichael Schirmer
Jun 20, 2006·Immunity·Casey T WeaverKenneth M Murphy
Jul 1, 2006·Journal of Leukocyte Biology·Akiko Toda, Ciriaco A Piccirillo
Jul 5, 2006·The Journal of Experimental Medicine·Nabila SeddikiBarbara Fazekas de St Groth
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhibin ChenChristophe Benoist
Jan 6, 2007·American Journal of Respiratory and Critical Care Medicine·Paul ForsytheJohn Bienenstock
Jan 30, 2007·Trends in Molecular Medicine·Makoto Miyara, Shimon Sakaguchi
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bin LiMark I Greene
Mar 17, 2007·Immunity·Arian LaurenceJohn J O'shea
Apr 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W FeleszkoE Hamelmann
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace

❮ Previous
Next ❯

Citations

Aug 9, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Min CaiPing-Chang Yang
Jun 21, 2018·American Journal of Reproductive Immunology : AJRI·Kassem SharifYehuda Shoenfeld
Dec 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Feng WangMark M Davis
Nov 6, 2018·Pflügers Archiv : European journal of physiology·Dominik LanggartnerStefan O Reber
Feb 17, 2018·Thyroid Research·Marta RydzewskaArtur Bossowski
Apr 14, 2019·Microorganisms·Aaron LernerTorsten Matthias
Aug 20, 2019·Molecular Nutrition & Food Research·Chengfei WuJia Sun
Oct 30, 2019·British Journal of Pharmacology·Eamonn M M Quigley
Apr 16, 2020·Microbial Cell Factories·Roberto MendezSantanu Banerjee
Mar 17, 2017·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Jun 9, 2018·Frontiers in Immunology·Christina TsigalouEugenia Bezirtzoglou
May 2, 2018·Frontiers in Microbiology·Silvia I CazorlaGabriela D V Perdigón
Sep 3, 2020·International Journal of Molecular Sciences·Shaghayegh Baradaran GhavamiMohammad Reza Zali
Mar 12, 2019·Oncology Letters·Yang TianYan Qing Li
Oct 16, 2018·Frontiers in Immunology·Brandi T Johnson-WeaverMichael D Kulis
Jan 31, 2019·Frontiers in Immunology·Dayong WuSimin Nikbin Meydani
Oct 13, 2020·Frontiers in Microbiology·Maria AponteMahtab Shoukat
Oct 1, 2020·Immunology and Cell Biology·Radha Pujari, Gautam Banerjee
Nov 17, 2020·Autoimmunity Reviews·Rui ZhangPing Zhu
Oct 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roghayeh ShahbaziChantal Matar
Mar 2, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gholamreza AskariAmir Reza Moravejolahkami
Dec 24, 2018·Journal of Theoretical Biology·Akane Hara, Yoh Iwasa
Jun 9, 2021·Reproductive Sciences·Dan LiYeling Wang
Jul 21, 2021·Probiotics and Antimicrobial Proteins·Gemma L LawsRoslyn A Kemp
Oct 21, 2021·Nutrition Research Reviews·Kamila Sabino BatistaJailane de Souza Aquino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here