Induction of second trimester abortion (12-20 weeks) with mifepristone and misoprostol: a review of 386 consecutive cases

Contraception
Sin Ee Goh, Kok Joo Thong

Abstract

A retrospective analysis of 386 women who underwent termination of pregnancy between 12 and 24 weeks' gestation. Each woman received 200 mg mifepristone orally followed by vaginal misoprostol 800 microg 36 to 48 h later. Three hours after the initial misoprostol administration, 400-microg doses of vaginal misoprostol were administered every 3 h, to a maximum of four doses in 24 h. If abortion failed, 200 mg mifepristone is given again 3 h after the last misoprostol dose, followed by 12 h of rest before vaginal misoprostol administration is repeated as per previous course of treatment. Overall, 97.9% and 99.5% of the women aborted within 24 and 36 h, respectively. The median induction-to-abortion interval was 6.7 h (range: 1.4-73.8 h), and nulliparous women took significantly longer time to abort (6.0 h in multiparous women compared to 7.6 h in nulliparous women; p<.0001). One woman failed to abort within 48 h. Surgical evacuation of the uterus was performed in 5% of women for incomplete abortion or retained placenta. Multiparous women were less likely to need analgesic administration for pain relief, and to experience vomiting and diarrhea, than nulliparous women. The combination of 200 mg mifepristone and vaginally administere...Continue Reading

References

Dec 1, 1992·British Journal of Obstetrics and Gynaecology·K J Thong, D T Baird
Apr 1, 1990·Medicinal Research Reviews·P W Collins
Aug 1, 1993·British Journal of Obstetrics and Gynaecology·K J Thong, D T Baird
Jul 31, 1999·British Journal of Obstetrics and Gynaecology·P W Ashok, A Templeton

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Citations

Oct 1, 2009·Reproductive Health·Annamarie MauelshagenCynthia M Farquhar
Jun 15, 2011·Contraception·Lynn BorgattaUNKNOWN Society of Family Planning
Dec 7, 2007·Obstetrics and Gynecology·Nathalie KappNilda Moreno
Jul 9, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·T K LoR K H Chin
Mar 30, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Vivian C Y LeeP C Ho
May 12, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Norbert WinerPatrick Rozenberg
Nov 23, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Sally B RoseAnn Simmons
Mar 12, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Jan E DickinsonElizabeth A Nathan
Oct 18, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bloeme J van der KnoopAttie T J I Go
Sep 20, 2018·Journal of Feline Medicine and Surgery·Serhan Serhat AyMurat Fındık
Jul 21, 2006·The Cochrane Database of Systematic Reviews·J P NeilsonJ Vazquez
Feb 7, 2008·The Cochrane Database of Systematic Reviews·P A LohrK Gemzell-Danielsson
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology

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