Induction of sensitization to hyperactivity caused by morphine in mice: effects of post-drug environments

Pharmacology, Biochemistry, and Behavior
H Kuribara

Abstract

Mice given five repeated administrations of morphine (10 mg/kg sc) at 3 day intervals in a round tilting-type activity cage (20 cm in diameter) or round spaces 15-30 cm in diameter with fixed floor showed almost the same level of ambulatory sensitization to morphine. Whereas, mice given morphine in the same schedule in spaces 4 and 12 cm, but not 6 and 9 cm, in diameter demonstrated a partial increase in the sensitivity to morphine. Furthermore, mice given morphine five times in a transparent cage (20W x 25L x 15H cm) with woodchip bedding, that was the same as the home cage, showed a weak and strong ambulatory sensitization when they were placed in group of ten and singly, respectively, for 3 h after each morphine administration. Repeated administrations of saline to mice in the space 4 cm in diameter resulted in increased sensitivity to morphine. However, the pretreatment with saline in the other environments (activity cage, spaces 6-30 cm in diameter with fixed floor, and home cage-like cage in which mice were placed singly or in group of ten) did not change the sensitivity to morphine. These results suggest that repeated experience of pharmacological effect of morphine and the resultant ambulation is one of the most importa...Continue Reading

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Citations

Jun 16, 2004·Behavioural Brain Research·Jun-Xu LiJian-Hui Liang
May 26, 2005·Behavioural Brain Research·Mohammad-Reza ZarrindastParvaneh Nourjah
Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·J J BattistiL J Wallace
Aug 23, 2002·Behavioural Brain Research·John E Kelsey, William A Carlezon
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne Michel, Ezio Tirelli
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amparo SerranoJosé Miñarro
Apr 2, 2003·Neuroscience Letters·Desmond J SmithXin Liu
Jun 7, 2007·Behavioural Pharmacology·Mohammad-Reza ZarrindastAkbar Hajizadeh-Moghaddam
May 30, 2006·Peptides·Tomasz DylagJerzy Silberring
Jun 14, 2020·European Journal of Pharmacology·Tomoyuki IjiroSumiyoshi Kiguchi

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