PMID: 75235Jan 1, 1978Paper

Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. II. An analysis of the effects measured at the cellular and serological levels

The Journal of Experimental Medicine
M AguetH Wigzell

Abstract

T lymphoblasts specific for foreign histocompatibility antigens and purified via mixed leukocyte culture (MLC) and 1 g velocity sedimentation procedures can be used as autoimmunogen to produce specific immunological unresponsiveness in adult animals. This unresponsiveness is positively correlated to the production of autoanti-idiotypic antibodies in the blast immunized animals and no evidence of coexisting alloimmunity was found. We consider this autoanti-idiotypic immunity to be the specific inducing agent of the immune tolerance. The blast immunization procedure will lead to selective reduction in T-cell reactivity against the relevant alloantigens as measured by MLC, cell-mediated lympholysis, or graft-versus-host assays. However, in individual animals, dichtomy in suppression between two T-cell assays could sometimes be observed indicating elimination of only a select group of idiotypic functionally distinct population of T cells in these blast-immunized animals. Attempts to abrogate already immune animals by the autoblast procedure were successful, in part suggesting the use of the present procedure when trying to induce in accelerated reversion of such immunity.

References

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Citations

Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P M FloodH Schreiber
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A F TilkinJ Urbain
Feb 1, 1978·The Journal of Experimental Medicine·H FrischknechtH Wigzell
Oct 1, 1980·The Journal of Experimental Medicine·D H KatzA Altman
Aug 1, 1981·The Journal of Experimental Medicine·P M FloodH Schreiber
Apr 1, 1982·The Journal of Experimental Medicine·A J InfanteC G Fathman
Sep 1, 1983·Kidney International·E G Neilson, B Zakheim
Jan 1, 1981·Cellular Immunology·A SootsP Häyry
May 1, 1982·Immunology Today·J Urbain, C Wuilmart
Jan 1, 1982·Annals of the New York Academy of Sciences·H Binz Wigzell
Dec 1, 1984·American Journal of Reproductive Immunology : AJRI·D P SingalS Joseph
Dec 22, 1978·Molecular and Cellular Biochemistry·H Binz, H Wigzell

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