PMID: 410028Sep 1, 1977

Induction of spectrin in erythroleukemic cells transformed by Friend virus

Proceedings of the National Academy of Sciences of the United States of America
H EisenR Emery

Abstract

The presence and accumulation in murine erythroleukemic cells transformed by Friend virus of the erythrocyte membrane-associated protein spectrin has been investigated. Spectrin was present in the uninduced cells and was induced 10- to 20-fold in dimethyl sulfoxide-treated differentiating cells. The intracellular concentration of spectrin reached a peak on the third day of dimethyl sulfoxide treatment, after which it fell to levels found in mouse erythrocytes. We also found that the small subunit of spectrin was phosphorylated in the cells.

References

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May 1, 1993·Journal of Cellular Physiology·M GrdisaR M Johnstone
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Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D W GoldeC Friend
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Related Concepts

Cell Differentiation Process
Cell Transformation, Viral
Rheumabene
Acute Erythroblastic Leukemia
Friend Murine Leukemia Virus
Cell Surface Proteins
Mast-Cell Sarcoma
Spectrin

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