Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide

Japanese Journal of Cancer Research : Gann
K TakegawaM Takahashi

Abstract

In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.

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Citations

Aug 10, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K TakegawaM Takahashi
Jun 1, 2012·Nucleosides, Nucleotides & Nucleic Acids·Toshinori SuzukiMichiyo Inukai
Dec 15, 2011·Regulatory Toxicology and Pharmacology : RTP·Alan Poole, Shakil A Saghir
Oct 3, 2018·Journal of Pathology and Translational Medicine·Swati SharmaAnjana Arora
Apr 7, 2006·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Patricia D MailCarol Nice Conner
Mar 27, 2001·Health Education & Behavior : the Official Publication of the Society for Public Health Education·M SullivanJ W Krieger
Dec 19, 2017·BioMed Research International·Gloria Romina RossPaola Gauffin Cano

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