Induction of squamous metaplasia, dysplasia and carcinoma in situ of the mouse tracheal mucosa by inhalation of sodium chloride mist following subcutaneous injection of 4-nitroquinoline 1-oxide

Japanese Journal of Cancer Research : Gann
T KarubeS Watanabe

Abstract

Squamous metaplasia, dysplasia and carcinoma in situ (CIS) were induced in the ICR/Jcl mouse tracheal mucosa by exposure to a mist of 5% NaCl solution following single subcutaneous injection of 4-nitroquinoline 1-oxide (4-NQO). Either subcutaneous injection of 4-NQO or NaCl inhalation alone did not cause any marked change in the tracheal mucosa. The NaCl inhalation is considered to have promotion-like action on the mouse tracheal mucosa after administration of 4-NQO injection.

References

Sep 1, 1988·Japanese Journal of Cancer Research : Gann·M MinowaW J Blot
Sep 1, 1982·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J M SeversonR J Toohill

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Citations

Feb 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A J Cohen, F J Roe
Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H EnzmannG M Williams
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B N Ames, L S Gold
Feb 6, 2010·Toxicologic Pathology·Roger RenneThomas Wohrmann
Jan 1, 1990·Medical Oncology and Tumor Pharmacotherapy·B N Ames, L S Gold

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