Induction of Stein-Leventhal-like polycystic ovaries (PCO) in the rat: a new model for cystic ovarian disease

The Anatomical Record
G F McCarthy, J R Brawer

Abstract

An injection of estradiol valerate (EV) in the rat produces an anovulatory polycystic ovarian (PCO) condition. Chronic estrogen exposure, produced by subcutaneously implanted, estradiol (E2)-containing chronic release capsules, results in acyclicity and in hypothalamic changes similar to those seen in the EV-injected rat. We, therefore, examined the ovarian histology and plasma gonadotropin patterns in the E2-implanted rat and found that this model exhibits a polycystic ovarian condition and a plasma gonadotropin pattern very different from those in the EV-treated model. The plasma patterns of LH and FSH are bimodal consisting of small frequent pulses as well as less frequent large episodes of long duration. The ovaries contain multiple small cysts, characterized by an extensively hypertrophied theca interna, and vast chords of hypertrophied secondary interstitial cells. In contrast, cystic follicles in EV-treated rats are fewer in number, but much larger than those in the E2-implanted animals. The cystic theca and the secondary interstitial cell clusters are also far less extensive in the EV-induced polycystic ovary. These and other differences between the two types of PCO indicate that they are produced by fundamentally diffe...Continue Reading

References

Jan 1, 1990·Canadian Journal of Physiology and Pharmacology·G F McCarthyJ R Brawer
Aug 1, 1989·Canadian Journal of Physiology and Pharmacology·P D CarriereJ R Brawer
Aug 1, 1989·American Journal of Obstetrics and Gynecology·J BrawerR Farookhi
Apr 1, 1988·Biology of Reproduction·P D CarriereR Farookhi
Jun 1, 1987·The Journal of Clinical Endocrinology and Metabolism·L Wildt, G Leyendecker
Jul 1, 1980·Endocrinology·J R BrawerF Naftolin
May 1, 1982·Endocrinology·G B Ellis, C Desjardins

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Citations

Jul 25, 1998·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·I HalikiasG Tolis
Jan 28, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Haolin ZhangJie Qiao
Oct 8, 2005·Fertility and Sterility·Krishna B Singh
Feb 18, 2012·Biology of Reproduction·Kirsty A WaltersDavid J Handelsman
Nov 2, 2013·Clinical and Experimental Reproductive Medicine·Ali NoorafshanSaied Karbalay-Doust
Nov 1, 1991·The Anatomical Record·M Convery, J R Brawer
Jan 22, 2011·Circulation Research·Ellen Neven, Patrick C D'Haese
Feb 12, 2017·Reproductive Biology and Endocrinology : RB&E·Larissa PaixãoPoli Mara Spritzer

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