Induction of stress response proteins and experimental renal ischemia/reperfusion

Kidney International
K J KellyA L Greene

Abstract

The induction of stress response (heat shock) proteins (HSPs) is a highly conserved response that protects many cell types from diverse physiological and environmental stressors. We tested the hypothesis that the induction of HSPs is protective in experimental renal ischemia/reperfusion injury. The effect of prior heat stress was examined in a rat model of renal ischemia. Postischemic renal function, histopathology, myeloperoxidase activity, and mortality were determined in hyperthermia and sham hyperthermia groups. HSP84, HSP70, and HSP22 mRNA were increased after eight minutes but not four minutes of hyperthermia. The induction of HSP84 and HSP70 was blocked by pretreatment with quercetin. Improvement in renal function, mortality, and histologic abnormalities was seen with eight minutes of hyperthermia six hours before ischemia. Protection was dependent on the timing of ischemia relative to heat stress and was not observed when HSPs were not induced. Postischemic increases in renal myeloperoxidase activity were markedly attenuated in the hyperthermia compared with the sham hyperthermia group. Endogenous protective mechanisms may be important in renal ischemia/reperfusion injury.

References

Jan 2, 1992·Nature·M J Gething, J Sambrook
Feb 1, 1985·Molecular and Cellular Biology·B WuR Morimoto
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein
Apr 1, 1995·The Journal of Clinical Investigation·J C PlumierG N Pagoulatos
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·K J KellyJ V Bonventre
Feb 15, 1996·The Journal of Clinical Investigation·K J KellyJ V Bonventre
Mar 20, 1997·The New England Journal of Medicine·R L AllgrenM H Sayegh
Dec 31, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G M Chertow
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·S K Van Why, N J Siegel
Dec 17, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M JavadpourD J Bouchier-Hayes

❮ Previous
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Citations

Mar 23, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christoph Aufricht
Dec 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sharon Phillips Andreoli
Aug 26, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael BoehmChristoph Aufricht
Jan 23, 2003·Current Urology Reports·R William G WatsonJohn M Fitzpatrick
Dec 20, 2011·Cell Stress & Chaperones·Bettina BidmonChristoph Aufricht
Mar 23, 2004·European Journal of Pharmacology·Motoaki SaitoIkuo Miyagawa
Aug 26, 2006·Nature Clinical Practice. Nephrology·Michael RiordanNorman J Siegel
Sep 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hidekazu SugiuraKen Tsuchiya
May 1, 2002·Current Opinion in Pediatrics·Sharon Phillips Andreoli
Feb 13, 2007·Current Opinion in Nephrology and Hypertension·Christopher Y LuJianlin Chen
May 11, 2005·Kidney International·Satoshi SuzukiSeiichi Matsuo
Feb 4, 2014·Journal of Forensic and Legal Medicine·Jonathon HerbstNeil E I Langlois
Jan 5, 2011·EMBO Molecular Medicine·Jonatan Barrera-ChimalNorma A Bobadilla
Sep 14, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·Ingebjørg S JuelJon Erik Grønbech
Apr 21, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jonatan Barrera-Chimal, Norma A Bobadilla
May 9, 2014·Kidney International·Rajasree SreedharanScott K Van Why
Jul 25, 2009·The Journal of Surgical Research·Gang ChenDavid J Bouchier-Hayes
Feb 13, 2007·The Journal of Surgical Research·T Florian FullerClaus U Niemann
Jan 31, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Andrea FeketeAttila J Szabó
Apr 21, 2007·Cardiovascular Drug Reviews·Ilan J DananChristophe Depre
Jan 25, 2005·Toxicology·Devinder SinghKanwaljit Chopra
Jan 27, 2005·Biochemical and Biophysical Research Communications·Kwon Moo ParkJoseph V Bonventre
Jun 23, 2004·Brain Research. Molecular Brain Research·Christopher S LivermanNancy E J Berman
Jan 3, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Leszek DomanskiKazimierz Ciechanowski
Sep 4, 2015·Canadian Journal of Kidney Health and Disease·Samuel A SilverJeffrey G Dickhout
Aug 11, 2004·Life Sciences·Motoaki SaitoKeisuke Satoh
Jun 2, 2006·Virchows Archiv : an International Journal of Pathology·Christian AugustHideo A Baba
Jul 19, 2008·Anesthesia and Analgesia·Michael P HutchensPer O Jarnberg
Jan 20, 2006·Journal of the American Society of Nephrology : JASN·Declan A HealyR William G Watson
Nov 2, 2005·The Journal of Pathology·R Franco-GouC Peralta
Apr 12, 2003·Pflügers Archiv : European journal of physiology·Hua ZhouAkira Hishida
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chul Woo YangByung Kee Bang
Oct 12, 2019·Canadian Journal of Physiology and Pharmacology·Parnia MobasheranHamed Shafaroodi
May 17, 2002·Journal of Applied Physiology·Sherry D FlemingTerez Shea-Donohue
May 23, 2003·Journal of the American Society of Nephrology : JASN·K J Kelly

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