PMID: 11604164Oct 18, 2001Paper

Induction of systemic and mucosal immune response in cattle by intranasal administration of pig serum albumin in alginate microparticles

Veterinary Immunology and Immunopathology
M C RebelattoHarm HogenEsch

Abstract

Biodegradable microparticles are an efficient mucosal delivery system that protect antigens from the harsh mucosal environment and facilitate their uptake by M cells at the epithelium of mucosal-associated lymphoid tissue. In this study, we determined the systemic and mucosal immune response in calves following intranasal and oral immunization with pig serum albumin (PSA) encapsulated in alginate microparticles. The size of the particles ranged from 1 to 50 microm in diameter, with 95% of the particles being smaller than 5 microm. High levels of anti-PSA IgG1 antibodies were found in the serum, nasal secretions, and to a less extent in saliva of calves vaccinated intranasally, but not orally, with PSA-microparticles. There was no significant increase of PSA-specific IgA. A weak lymphocyte proliferative immune response was observed in peripheral blood mononuclear cells (PBMCs), and few anti-PSA antibody-secreting cells (ASC) were detected in the blood of calves immunized intranasally. The combined systemic and mucosal response observed in intranasally immunized animals may be attributed to the wide variation in the size of the alginate microparticles, with smaller particles translocating to regional lymph nodes and inducing a sy...Continue Reading

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Citations

Mar 26, 2013·International Journal of Pharmaceutics·Tittaya SuksamranPraneet Opanasopit
Jun 5, 2003·International Journal for Parasitology·Manmohan Singh, Derek T O'Hagan
Feb 27, 2004·Immunology and Cell Biology·Bradley J SedgmenShari A Lofthouse
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Oct 16, 2010·Journal of Microencapsulation·Huey-Chuan ChengDer-Zen Liu
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