Apr 1, 1974

Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus

Proceedings of the National Academy of Sciences of the United States of America
R S Basch, G Goldstein

Abstract

Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.

  • References15
  • Citations97

Mentioned in this Paper

Antigens, Differentiation
T-Lymphocyte
Spleen
Neoplasm of Uncertain or Unknown Behavior of Thymus
Bone Marrow
Thymocyte
Immune Sera
Bos taurus
Disease of Thymus Gland
Thymic Tissue

About this Paper

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.