Induction of T cells suppression by dendritic cells transfected with VSIG4 recombinant adenovirus

Immunology Letters
Shuxiong XuXiongfei Wu

Abstract

VSIG4 has been recently described as a B7 family-related protein. The immunotherapeutic potential of dendritic cells (DCs) transfected with VSIG4 recombinant adenovirus has not been characterized. In the present study, DCs were transfected with human VSIG4 (hVSIG4) recombinant adenovirus, a novel costimulatory molecule known to be a potent inhibitor of T cell activation. Transfected DCs were cocultured with allogeneic T cells and proliferation, cytokine production and T cell activation marker expression were assessed. The results showed that T cell proliferation potential, cytokine production and activation marker expression were suppressed after coculture with hVSIG4 recombinant adenovirus-transfected DCs. These findings suggest that DCs transfected with hVSIG4 recombinant adenovirus are capable of inducing allogeneic T cell suppression, which represents an ideal strategy for manipulating the immune response to transplanation or autoimmune diseases.

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Citations

Jul 12, 2011·Cancer Cell·Kenneth L ScottLynda Chin
Jul 12, 2011·The American Journal of Pathology·Nick N GorganiAntonio Ferrante
Sep 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judit SvenssonJan Ernerudh
Jan 11, 2020·Frontiers in Immunology·Usma MunawaraAntonio Ferrante

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