Induction of Th1 immune responses to Japanese cedar pollen allergen (Cry j 1) in mice immunized with Cry j 1 conjugated with CpG oligodeoxynucleotide

Comparative Immunology, Microbiology and Infectious Diseases
Y KaburakiMasahiro Sakaguchi

Abstract

We determined whether a major Japanese cedar pollen allergen (Cry j 1) conjugated with CpG oligodeoxynucleotide would enhance allergen-specific Th1 responses in mice. Cry j 1 conjugated with CpG (Cry j 1-CpG) induced IL-12 in the spleen cells of naïve mice. Cry j 1-CpG immunization of BALB/c mice suppressed anti-Cry j 1 IgE response and enhanced anti-Cry j 1 IgG(2a) to subsequent Cry j 1 and alum adjuvant injection. CD4(+)T cells isolated from the spleens in mice immunized with Cry j 1-CpG produced higher IFN-γ levels than did CD4(+)T cells obtained from mice as negative controls. Our results suggested that Cry j 1-CpG immunization can induce Cry j 1-specific Th1 immune responses, thereby inhibiting IgE response to the pollen allergen.

References

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Citations

Jan 14, 2011·Auris, Nasus, Larynx·Masahiro SakaguchiMasako Toda
Nov 23, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Chengbo YangYoshinori Mine
Nov 30, 2011·International Archives of Allergy and Immunology·Yago Pico de CoañaNuria Parody
Aug 14, 2012·Current Opinion in Allergy and Clinical Immunology·Margarete Focke-Tejkl, Rudolf Valenta
Jul 14, 2020·Journal of Cellular Physiology·Zhongtao FengJafar Hajavi
Aug 31, 2017·Human Vaccines & Immunotherapeutics·Yan SuTeri Heiland

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