Induction of the CD1a Langerhans cell marker on human monocytes

Archives of Oral Biology
S Athanasas-PlatsisL J Walsh

Abstract

Monocytes have recently been recognized as a precursor of Langerhans cells. This study examined the regulatory influence of the epithelial environment on the putative first step of the transition towards a Langerhans cell phenotype--the induction of CD1a antigen. The keratinocyte-derived cytokines granulocyte-macrophage-colony-stimulating factor, tumour necrosis factor-alpha, interleukin-6, and interleukin-1 beta induced CD1a expression, as did supernatants of keratinocytes extracted from inflammatory sites (periodontitis). Induction was abrogated by transforming growth factor-beta and a keratinocyte-derived interleukin-1 inhibitor. The optimal temperature for induction was 34 degrees C, not 37 degrees C. These results demonstrate that the components of the epithelial environment (cytokines and lower temperature) exert important influences, which may be part of local regulation of Langerhans cell development.

References

Feb 1, 1992·Immunology Letters·G RossiF Steinbach
Sep 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T IshiiR N Powell
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J WalshG F Murphy
Jan 1, 1988·Journal of Oral Pathology·L J WalshR N Powell

❮ Previous
Next ❯

Citations

Jan 25, 2014·Case Reports in Medicine·Marguerite B Vigliani, Anna I Bakardjiev
Apr 27, 2004·Periodontology 2000·Christopher W Cutler, Ravi Jotwani
Jan 20, 2011·European Journal of Immunology·Konstantin YakimchukD Branch Moody
Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Gordana LaskarinDaniel Rukavina
Jun 16, 1999·Ultrastructural Pathology·F PrignanoP Romagnoli
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A W BarrettD M Williams
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Laurence J Walsh
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela ColmoneChyung-Ru Wang
Jan 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xue ZhangHui Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
M A de Rie
Infectious Diseases in Obstetrics and Gynecology
L ZettellN B Isada
Veterinary Parasitology
A SalequeB B Bhatia
© 2021 Meta ULC. All rights reserved